Gum Arabic supplementation prevents loss of learning and memory through stimulation of mitochondrial function in the hippocampus of type 2 diabetic rats

Gum Arabic supplementation prevents loss of learning and memory through stimulation of mitochondrial function in the hippocampus of type 2 diabetic rats

The aim was to determine whether gum Arabic (GA) supplementation prevents cognitive decline in type 2 diabetes, through stimulation of mitochondrial function in the hippocampus. Type 2 diabetic rats and controls were assigned to following groups for 16 weeks: Control + Water; Control + GA 10% w/v; D...

Full description

Bibliographic Details
Main Authors: Ebrahim Rajab, Michael B. Keogh, Ashang L. Laiva, Fatima Al Hannan, Maryam Fateel, Fatema Abdulwahab, Fatema Al Madhoob, Bassam AlHamer, Samar Y. Ghazzal, Abdulla Dawaishan, Sadiq Mahdi, Abdulrahman Qareeballa, Sayed M. Almosawi, Faisal Falamarzi, Khalifa ElMusharaf, Amer Kamal
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Journal of Functional Foods
Subjects:
Gum Arabic
Diabetes
Hippocampus
Memory
Mitochondria
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464621004060
id doaj-a17be7c523a344cebb5e82772b02a852
record_format Article
spelling doaj-a17be7c523a344cebb5e82772b02a8522021-09-17T04:34:48ZengElsevierJournal of Functional Foods1756-46462021-12-0187104757Gum Arabic supplementation prevents loss of learning and memory through stimulation of mitochondrial function in the hippocampus of type 2 diabetic ratsEbrahim Rajab0Michael B. Keogh1Ashang L. Laiva2Fatima Al Hannan3Maryam Fateel4Fatema Abdulwahab5Fatema Al Madhoob6Bassam AlHamer7Samar Y. Ghazzal8Abdulla Dawaishan9Sadiq Mahdi10Abdulrahman Qareeballa11Sayed M. Almosawi12Faisal Falamarzi13Khalifa ElMusharaf14Amer Kamal15School of Medicine, RCSI Bahrain, P.O. Box 15503, Adliya, Bahrain; Corresponding author.School of Medicine, RCSI Bahrain, P.O. Box 15503, Adliya, BahrainSchool of Medicine, RCSI Bahrain, P.O. Box 15503, Adliya, BahrainSchool of Medicine, RCSI Bahrain, P.O. Box 15503, Adliya, BahrainSchool of Medicine, RCSI Bahrain, P.O. Box 15503, Adliya, BahrainSchool of Medicine, RCSI Bahrain, P.O. Box 15503, Adliya, BahrainSchool of Medicine, RCSI Bahrain, P.O. Box 15503, Adliya, BahrainSchool of Medicine, RCSI Bahrain, P.O. Box 15503, Adliya, BahrainSchool of Medicine, RCSI Bahrain, P.O. Box 15503, Adliya, BahrainSchool of Medicine, RCSI Bahrain, P.O. Box 15503, Adliya, BahrainPhysiology Department, College of Medicine and Medical Sciences, Arabian Gulf University, P.O. Box 26671, Manama, BahrainPhysiology Department, College of Medicine and Medical Sciences, Arabian Gulf University, P.O. Box 26671, Manama, BahrainPhysiology Department, College of Medicine and Medical Sciences, Arabian Gulf University, P.O. Box 26671, Manama, BahrainPhysiology Department, College of Medicine and Medical Sciences, Arabian Gulf University, P.O. Box 26671, Manama, BahrainSchool of Medicine, University of Limerick, Limerick V94 T9PX, IrelandPhysiology Department, College of Medicine and Medical Sciences, Arabian Gulf University, P.O. Box 26671, Manama, BahrainThe aim was to determine whether gum Arabic (GA) supplementation prevents cognitive decline in type 2 diabetes, through stimulation of mitochondrial function in the hippocampus. Type 2 diabetic rats and controls were assigned to following groups for 16 weeks: Control + Water; Control + GA 10% w/v; Diabetes + Water; Diabetes + GA 10% w/v. Latency in water maze was shorter for Diabetes + GA compared to Diabetes + Water (P < 0.05). Diabetes + GA group had a higher expression density per cell of peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) compared to Diabetes + Water (P < 0.05). A similar trend was observed for ATP synthase β-subunit expression (ATPB). Number of PGC-1α positive cells was higher in diabetes compared to control groups (p < 0.05). The GA prevented learning and memory loss in type 2 diabetes. This was associated with greater expression of PGC-1a and a trend for greater ATBP protein expression in the hippocampus.http://www.sciencedirect.com/science/article/pii/S1756464621004060Gum ArabicDiabetesHippocampusMemoryMitochondria
collection DOAJ
language English
format Article
sources DOAJ
author Ebrahim Rajab
Michael B. Keogh
Ashang L. Laiva
Fatima Al Hannan
Maryam Fateel
Fatema Abdulwahab
Fatema Al Madhoob
Bassam AlHamer
Samar Y. Ghazzal
Abdulla Dawaishan
Sadiq Mahdi
Abdulrahman Qareeballa
Sayed M. Almosawi
Faisal Falamarzi
Khalifa ElMusharaf
Amer Kamal
spellingShingle Ebrahim Rajab
Michael B. Keogh
Ashang L. Laiva
Fatima Al Hannan
Maryam Fateel
Fatema Abdulwahab
Fatema Al Madhoob
Bassam AlHamer
Samar Y. Ghazzal
Abdulla Dawaishan
Sadiq Mahdi
Abdulrahman Qareeballa
Sayed M. Almosawi
Faisal Falamarzi
Khalifa ElMusharaf
Amer Kamal
Gum Arabic supplementation prevents loss of learning and memory through stimulation of mitochondrial function in the hippocampus of type 2 diabetic rats
Journal of Functional Foods
Gum Arabic
Diabetes
Hippocampus
Memory
Mitochondria
author_facet Ebrahim Rajab
Michael B. Keogh
Ashang L. Laiva
Fatima Al Hannan
Maryam Fateel
Fatema Abdulwahab
Fatema Al Madhoob
Bassam AlHamer
Samar Y. Ghazzal
Abdulla Dawaishan
Sadiq Mahdi
Abdulrahman Qareeballa
Sayed M. Almosawi
Faisal Falamarzi
Khalifa ElMusharaf
Amer Kamal
author_sort Ebrahim Rajab
title Gum Arabic supplementation prevents loss of learning and memory through stimulation of mitochondrial function in the hippocampus of type 2 diabetic rats
title_short Gum Arabic supplementation prevents loss of learning and memory through stimulation of mitochondrial function in the hippocampus of type 2 diabetic rats
title_full Gum Arabic supplementation prevents loss of learning and memory through stimulation of mitochondrial function in the hippocampus of type 2 diabetic rats
title_fullStr Gum Arabic supplementation prevents loss of learning and memory through stimulation of mitochondrial function in the hippocampus of type 2 diabetic rats
title_full_unstemmed Gum Arabic supplementation prevents loss of learning and memory through stimulation of mitochondrial function in the hippocampus of type 2 diabetic rats
title_sort gum arabic supplementation prevents loss of learning and memory through stimulation of mitochondrial function in the hippocampus of type 2 diabetic rats
publisher Elsevier
series Journal of Functional Foods
issn 1756-4646
publishDate 2021-12-01
description The aim was to determine whether gum Arabic (GA) supplementation prevents cognitive decline in type 2 diabetes, through stimulation of mitochondrial function in the hippocampus. Type 2 diabetic rats and controls were assigned to following groups for 16 weeks: Control + Water; Control + GA 10% w/v; Diabetes + Water; Diabetes + GA 10% w/v. Latency in water maze was shorter for Diabetes + GA compared to Diabetes + Water (P < 0.05). Diabetes + GA group had a higher expression density per cell of peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) compared to Diabetes + Water (P < 0.05). A similar trend was observed for ATP synthase β-subunit expression (ATPB). Number of PGC-1α positive cells was higher in diabetes compared to control groups (p < 0.05). The GA prevented learning and memory loss in type 2 diabetes. This was associated with greater expression of PGC-1a and a trend for greater ATBP protein expression in the hippocampus.
topic Gum Arabic
Diabetes
Hippocampus
Memory
Mitochondria
url http://www.sciencedirect.com/science/article/pii/S1756464621004060
work_keys_str_mv AT ebrahimrajab gumarabicsupplementationpreventslossoflearningandmemorythroughstimulationofmitochondrialfunctioninthehippocampusoftype2diabeticrats
AT michaelbkeogh gumarabicsupplementationpreventslossoflearningandmemorythroughstimulationofmitochondrialfunctioninthehippocampusoftype2diabeticrats
AT ashangllaiva gumarabicsupplementationpreventslossoflearningandmemorythroughstimulationofmitochondrialfunctioninthehippocampusoftype2diabeticrats
AT fatimaalhannan gumarabicsupplementationpreventslossoflearningandmemorythroughstimulationofmitochondrialfunctioninthehippocampusoftype2diabeticrats
AT maryamfateel gumarabicsupplementationpreventslossoflearningandmemorythroughstimulationofmitochondrialfunctioninthehippocampusoftype2diabeticrats
AT fatemaabdulwahab gumarabicsupplementationpreventslossoflearningandmemorythroughstimulationofmitochondrialfunctioninthehippocampusoftype2diabeticrats
AT fatemaalmadhoob gumarabicsupplementationpreventslossoflearningandmemorythroughstimulationofmitochondrialfunctioninthehippocampusoftype2diabeticrats
AT bassamalhamer gumarabicsupplementationpreventslossoflearningandmemorythroughstimulationofmitochondrialfunctioninthehippocampusoftype2diabeticrats
AT samaryghazzal gumarabicsupplementationpreventslossoflearningandmemorythroughstimulationofmitochondrialfunctioninthehippocampusoftype2diabeticrats
AT abdulladawaishan gumarabicsupplementationpreventslossoflearningandmemorythroughstimulationofmitochondrialfunctioninthehippocampusoftype2diabeticrats
AT sadiqmahdi gumarabicsupplementationpreventslossoflearningandmemorythroughstimulationofmitochondrialfunctioninthehippocampusoftype2diabeticrats
AT abdulrahmanqareeballa gumarabicsupplementationpreventslossoflearningandmemorythroughstimulationofmitochondrialfunctioninthehippocampusoftype2diabeticrats
AT sayedmalmosawi gumarabicsupplementationpreventslossoflearningandmemorythroughstimulationofmitochondrialfunctioninthehippocampusoftype2diabeticrats
AT faisalfalamarzi gumarabicsupplementationpreventslossoflearningandmemorythroughstimulationofmitochondrialfunctioninthehippocampusoftype2diabeticrats
AT khalifaelmusharaf gumarabicsupplementationpreventslossoflearningandmemorythroughstimulationofmitochondrialfunctioninthehippocampusoftype2diabeticrats
AT amerkamal gumarabicsupplementationpreventslossoflearningandmemorythroughstimulationofmitochondrialfunctioninthehippocampusoftype2diabeticrats
_version_ 1717377752245469184

Similar Items