Evaluation of antiviral efficacy of ribavirin, arbidol, and T-705 (favipiravir) in a mouse model for Crimean-Congo hemorrhagic fever.

Evaluation of antiviral efficacy of ribavirin, arbidol, and T-705 (favipiravir) in a mouse model for Crimean-Congo hemorrhagic fever.

BACKGROUND: Mice lacking the type I interferon receptor (IFNAR-/- mice) reproduce relevant aspects of Crimean-Congo hemorrhagic fever (CCHF) in humans, including liver damage. We aimed at characterizing the liver pathology in CCHF virus-infected IFNAR-/- mice by immunohistochemistry and employed the...

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Main Authors: Lisa Oestereich, Toni Rieger, Melanie Neumann, Christian Bernreuther, Maria Lehmann, Susanne Krasemann, Stephanie Wurr, Petra Emmerich, Xavier de Lamballerie, Stephan Ölschläger, Stephan Günther
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-05-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC4006714?pdf=render

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