The Impact of Darwinian Evolution on Medicine: The Maternal Side of the Story

Complex disorders are common in the human population and are caused by interplay between genetic and environmental factors. Therefore the quest for the genetic basis of such disorders has much similarity to deciphering the genetic basis of macro-evolutionary processes, such as speciation. Here I dis...

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Bibliographic Details
Main Author:	Dan Mishmar
Format:	Article
Language:	English
Published:	Rambam Health Care Campus 2010-07-01
Series:	Rambam Maimonides Medical Journal
Subjects:	evolutionary medicine mitochondria next-generation sequencing disease
Online Access:	http://rmmj.org.il/(S(zb0aovonda35dgcyogzl5gxm))/Pages/ArticleHTM.aspx?manuId=11

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spelling	doaj-a174d1f13f514c2d932a68764d1b4f702020-11-24T22:36:00ZengRambam Health Care CampusRambam Maimonides Medical Journal2076-91722010-07-0111e001010.5041/RMMJ.10010The Impact of Darwinian Evolution on Medicine: The Maternal Side of the StoryDan Mishmar0Department of Life Sciences and the National Institute of Biotechnology (NIBN), Ben-Gurion University of the Negev, Beer Sheva, IsraelComplex disorders are common in the human population and are caused by interplay between genetic and environmental factors. Therefore the quest for the genetic basis of such disorders has much similarity to deciphering the genetic basis of macro-evolutionary processes, such as speciation. Here I discuss conceptual connections between the principles underlying and processes occurring in disease and evolution. Special focus is given to the tremendous mitochondrial genetic variability in the population and within individuals and the impact of both types of variability on evolutionary processes and diseases.http://rmmj.org.il/(S(zb0aovonda35dgcyogzl5gxm))/Pages/ArticleHTM.aspx?manuId=11evolutionary medicinemitochondrianext-generation sequencingdisease
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Dan Mishmar
spellingShingle	Dan Mishmar The Impact of Darwinian Evolution on Medicine: The Maternal Side of the Story Rambam Maimonides Medical Journal evolutionary medicine mitochondria next-generation sequencing disease
author_facet	Dan Mishmar
author_sort	Dan Mishmar
title	The Impact of Darwinian Evolution on Medicine: The Maternal Side of the Story
title_short	The Impact of Darwinian Evolution on Medicine: The Maternal Side of the Story
title_full	The Impact of Darwinian Evolution on Medicine: The Maternal Side of the Story
title_fullStr	The Impact of Darwinian Evolution on Medicine: The Maternal Side of the Story
title_full_unstemmed	The Impact of Darwinian Evolution on Medicine: The Maternal Side of the Story
title_sort	impact of darwinian evolution on medicine: the maternal side of the story
publisher	Rambam Health Care Campus
series	Rambam Maimonides Medical Journal
issn	2076-9172
publishDate	2010-07-01
description	Complex disorders are common in the human population and are caused by interplay between genetic and environmental factors. Therefore the quest for the genetic basis of such disorders has much similarity to deciphering the genetic basis of macro-evolutionary processes, such as speciation. Here I discuss conceptual connections between the principles underlying and processes occurring in disease and evolution. Special focus is given to the tremendous mitochondrial genetic variability in the population and within individuals and the impact of both types of variability on evolutionary processes and diseases.
topic	evolutionary medicine mitochondria next-generation sequencing disease
url	http://rmmj.org.il/(S(zb0aovonda35dgcyogzl5gxm))/Pages/ArticleHTM.aspx?manuId=11
work_keys_str_mv	AT danmishmar theimpactofdarwinianevolutiononmedicinethematernalsideofthestory AT danmishmar impactofdarwinianevolutiononmedicinethematernalsideofthestory
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The Impact of Darwinian Evolution on Medicine: The Maternal Side of the Story

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