Platelets are recruited to hepatocellular carcinoma tissues in a CX3CL1‐CX3CR1 dependent manner and induce tumour cell apoptosis

Platelets are recruited to hepatocellular carcinoma tissues in a CX3CL1‐CX3CR1 dependent manner and induce tumour cell apoptosis

The mechanisms and biological functions of migrating platelets in cancer remain largely unknown. Here, we analyzed platelet infiltration in hepatocellular carcinoma. We detected platelet extravasation in both mouse and human HCC tissues. CX3CL1 directly induced platelet migration, and hypoxia enhanc...

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Bibliographic Details
Main Authors: Shuo Miao, Meng Lu, Yue Liu, Dan Shu, Ying Zhu, Wei Song, Yuanyuan Ma, Rong Ma, Bixiang Zhang, Chao Fang, Zhang‐Yin Ming
Format: Article
Language:English
Published: Wiley 2020-10-01
Series:Molecular Oncology
Subjects:
CX3CL1/CX3CR1
HCC
migration
platelet
Online Access:https://doi.org/10.1002/1878-0261.12783

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