Alcohol enhances type 1 interferon-α production and mortality in young mice infected with Mycobacterium tuberculosis.

Alcohol enhances type 1 interferon-α production and mortality in young mice infected with Mycobacterium tuberculosis.

In the current study, we used a mouse model and human blood samples to determine the effects of chronic alcohol consumption on immune responses during Mycobacterium tuberculosis (Mtb) infection. Alcohol increased the mortality of young mice but not old mice with Mtb infection. CD11b+Ly6G+ cells are...

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Bibliographic Details
Main Authors: Deepak Tripathi, Elwyn Welch, Satyanarayana Swamy Cheekatla, Rajesh Kumar Radhakrishnan, Sambasivan Venkatasubramanian, Padmaja Paidipally, Abhinav Van, Buka Samten, Kamakshi P Devalraju, Venkata Sanjeev Kumar Neela, Vijaya Lakshmi Valluri, Carol Mason, Steve Nelson, Ramakrishna Vankayalapati
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-08-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC6072099?pdf=render

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