Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1
Inhibition of the lipid peroxidase GPX4 promotes ferroptotic cell death. Here, the authors identify a complementary approach using conjugated linolenic fatty acids that trigger lipid peroxidation and ferroptosis via ACSL1, DGAT1/2, and neutral lipids.
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22471-y |
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doaj-a15fa8f172aa4a2c98e5449033292272 |
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Article |
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doaj-a15fa8f172aa4a2c98e54490332922722021-04-18T11:14:03ZengNature Publishing GroupNature Communications2041-17232021-04-0112111810.1038/s41467-021-22471-yFerroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1Alexander Beatty0Tanu Singh1Yulia Y. Tyurina2Vladimir A. Tyurin3Svetlana Samovich4Emmanuelle Nicolas5Kristen Maslar6Yan Zhou7Kathy Q. Cai8Yinfei Tan9Sebastian Doll10Marcus Conrad11Aravind Subramanian12Hülya Bayır13Valerian E. Kagan14Ulrike Rennefahrt15Jeffrey R. Peterson16Fox Chase Cancer CenterFox Chase Cancer CenterDepartment of Environmental and Occupational Health, University of PittsburghDepartment of Environmental and Occupational Health, University of PittsburghDepartment of Environmental and Occupational Health, University of PittsburghFox Chase Cancer CenterDepartment of Biochemistry and Molecular Biology, Drexel University College of MedicineFox Chase Cancer CenterFox Chase Cancer CenterFox Chase Cancer CenterInstitute of Metabolism and Cell Death, Helmholtz Zentrum MünchenInstitute of Metabolism and Cell Death, Helmholtz Zentrum MünchenBroad Institute of Harvard and MITDepartment of Environmental and Occupational Health, University of PittsburghDepartment of Environmental and Occupational Health, University of PittsburghMetanomics Health GmbHFox Chase Cancer CenterInhibition of the lipid peroxidase GPX4 promotes ferroptotic cell death. Here, the authors identify a complementary approach using conjugated linolenic fatty acids that trigger lipid peroxidation and ferroptosis via ACSL1, DGAT1/2, and neutral lipids.https://doi.org/10.1038/s41467-021-22471-y |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Alexander Beatty Tanu Singh Yulia Y. Tyurina Vladimir A. Tyurin Svetlana Samovich Emmanuelle Nicolas Kristen Maslar Yan Zhou Kathy Q. Cai Yinfei Tan Sebastian Doll Marcus Conrad Aravind Subramanian Hülya Bayır Valerian E. Kagan Ulrike Rennefahrt Jeffrey R. Peterson |
| spellingShingle |
Alexander Beatty Tanu Singh Yulia Y. Tyurina Vladimir A. Tyurin Svetlana Samovich Emmanuelle Nicolas Kristen Maslar Yan Zhou Kathy Q. Cai Yinfei Tan Sebastian Doll Marcus Conrad Aravind Subramanian Hülya Bayır Valerian E. Kagan Ulrike Rennefahrt Jeffrey R. Peterson Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1 Nature Communications |
| author_facet |
Alexander Beatty Tanu Singh Yulia Y. Tyurina Vladimir A. Tyurin Svetlana Samovich Emmanuelle Nicolas Kristen Maslar Yan Zhou Kathy Q. Cai Yinfei Tan Sebastian Doll Marcus Conrad Aravind Subramanian Hülya Bayır Valerian E. Kagan Ulrike Rennefahrt Jeffrey R. Peterson |
| author_sort |
Alexander Beatty |
| title |
Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1 |
| title_short |
Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1 |
| title_full |
Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1 |
| title_fullStr |
Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1 |
| title_full_unstemmed |
Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1 |
| title_sort |
ferroptotic cell death triggered by conjugated linolenic acids is mediated by acsl1 |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-04-01 |
| description |
Inhibition of the lipid peroxidase GPX4 promotes ferroptotic cell death. Here, the authors identify a complementary approach using conjugated linolenic fatty acids that trigger lipid peroxidation and ferroptosis via ACSL1, DGAT1/2, and neutral lipids. |
| url |
https://doi.org/10.1038/s41467-021-22471-y |
| work_keys_str_mv |
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