Transplanted photoreceptor precursors transfer proteins to host photoreceptors by a mechanism of cytoplasmic fusion

Previous studies have used fluorescently labelled cells to demonstrate the incorporation of transplanted photoreceptor precursors into the mouse retina. Here, the authors show that fluorescent proteins are passed between the host and transplanted cells rather than migration of donor cells into the r...

Full description

Bibliographic Details
Main Authors:	Mandeep S. Singh, Jasmin Balmer, Alun R. Barnard, Sher A. Aslam, Daniela Moralli, Catherine M. Green, Alona Barnea-Cramer, Isabel Duncan, Robert E. MacLaren
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-11-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms13537

id	doaj-a152f0eaffda4bcba6ad872e86359ba3
record_format	Article
spelling	doaj-a152f0eaffda4bcba6ad872e86359ba32021-05-11T11:09:39ZengNature Publishing GroupNature Communications2041-17232016-11-01711510.1038/ncomms13537Transplanted photoreceptor precursors transfer proteins to host photoreceptors by a mechanism of cytoplasmic fusionMandeep S. Singh0Jasmin Balmer1Alun R. Barnard2Sher A. Aslam3Daniela Moralli4Catherine M. Green5Alona Barnea-Cramer6Isabel Duncan7Robert E. MacLaren8Department of Clinical Neurosciences, Nuffield Laboratory of Ophthalmology, Levels 5-6 West Wing, University of Oxford, John Radcliffe HospitalDepartment of Clinical Neurosciences, Nuffield Laboratory of Ophthalmology, Levels 5-6 West Wing, University of Oxford, John Radcliffe HospitalDepartment of Clinical Neurosciences, Nuffield Laboratory of Ophthalmology, Levels 5-6 West Wing, University of Oxford, John Radcliffe HospitalDepartment of Clinical Neurosciences, Nuffield Laboratory of Ophthalmology, Levels 5-6 West Wing, University of Oxford, John Radcliffe HospitalWellcome Trust Centre for Human GeneticsWellcome Trust Centre for Human GeneticsDepartment of Clinical Neurosciences, Nuffield Laboratory of Ophthalmology, Levels 5-6 West Wing, University of Oxford, John Radcliffe HospitalDepartment of Clinical Neurosciences, Nuffield Laboratory of Ophthalmology, Levels 5-6 West Wing, University of Oxford, John Radcliffe HospitalDepartment of Clinical Neurosciences, Nuffield Laboratory of Ophthalmology, Levels 5-6 West Wing, University of Oxford, John Radcliffe HospitalPrevious studies have used fluorescently labelled cells to demonstrate the incorporation of transplanted photoreceptor precursors into the mouse retina. Here, the authors show that fluorescent proteins are passed between the host and transplanted cells rather than migration of donor cells into the retina.https://doi.org/10.1038/ncomms13537
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Mandeep S. Singh Jasmin Balmer Alun R. Barnard Sher A. Aslam Daniela Moralli Catherine M. Green Alona Barnea-Cramer Isabel Duncan Robert E. MacLaren
spellingShingle	Mandeep S. Singh Jasmin Balmer Alun R. Barnard Sher A. Aslam Daniela Moralli Catherine M. Green Alona Barnea-Cramer Isabel Duncan Robert E. MacLaren Transplanted photoreceptor precursors transfer proteins to host photoreceptors by a mechanism of cytoplasmic fusion Nature Communications
author_facet	Mandeep S. Singh Jasmin Balmer Alun R. Barnard Sher A. Aslam Daniela Moralli Catherine M. Green Alona Barnea-Cramer Isabel Duncan Robert E. MacLaren
author_sort	Mandeep S. Singh
title	Transplanted photoreceptor precursors transfer proteins to host photoreceptors by a mechanism of cytoplasmic fusion
title_short	Transplanted photoreceptor precursors transfer proteins to host photoreceptors by a mechanism of cytoplasmic fusion
title_full	Transplanted photoreceptor precursors transfer proteins to host photoreceptors by a mechanism of cytoplasmic fusion
title_fullStr	Transplanted photoreceptor precursors transfer proteins to host photoreceptors by a mechanism of cytoplasmic fusion
title_full_unstemmed	Transplanted photoreceptor precursors transfer proteins to host photoreceptors by a mechanism of cytoplasmic fusion
title_sort	transplanted photoreceptor precursors transfer proteins to host photoreceptors by a mechanism of cytoplasmic fusion
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-11-01
description	Previous studies have used fluorescently labelled cells to demonstrate the incorporation of transplanted photoreceptor precursors into the mouse retina. Here, the authors show that fluorescent proteins are passed between the host and transplanted cells rather than migration of donor cells into the retina.
url	https://doi.org/10.1038/ncomms13537
work_keys_str_mv	AT mandeepssingh transplantedphotoreceptorprecursorstransferproteinstohostphotoreceptorsbyamechanismofcytoplasmicfusion AT jasminbalmer transplantedphotoreceptorprecursorstransferproteinstohostphotoreceptorsbyamechanismofcytoplasmicfusion AT alunrbarnard transplantedphotoreceptorprecursorstransferproteinstohostphotoreceptorsbyamechanismofcytoplasmicfusion AT sheraaslam transplantedphotoreceptorprecursorstransferproteinstohostphotoreceptorsbyamechanismofcytoplasmicfusion AT danielamoralli transplantedphotoreceptorprecursorstransferproteinstohostphotoreceptorsbyamechanismofcytoplasmicfusion AT catherinemgreen transplantedphotoreceptorprecursorstransferproteinstohostphotoreceptorsbyamechanismofcytoplasmicfusion AT alonabarneacramer transplantedphotoreceptorprecursorstransferproteinstohostphotoreceptorsbyamechanismofcytoplasmicfusion AT isabelduncan transplantedphotoreceptorprecursorstransferproteinstohostphotoreceptorsbyamechanismofcytoplasmicfusion AT robertemaclaren transplantedphotoreceptorprecursorstransferproteinstohostphotoreceptorsbyamechanismofcytoplasmicfusion
_version_	1721446996268548096

Transplanted photoreceptor precursors transfer proteins to host photoreceptors by a mechanism of cytoplasmic fusion

Similar Items