LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells
Liver cancer stem cells (CSCs) may contribute to the high rate of recurrence of hepatocellular carcinoma. Here, the authors show that the long coding RNA, LcnBRM, regulates the self-renewal of liver CSCs and tumour initiation through binding to BAF complex thereby activating YAP1.
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Nature Publishing Group
2016-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13608 |
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doaj-a14e02b6cfc44b4dbfedd36546c255162021-05-11T10:49:07ZengNature Publishing GroupNature Communications2041-17232016-12-017111310.1038/ncomms13608LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cellsPingping Zhu0Yanying Wang1Jiayi Wu2Guanling Huang3Benyu Liu4Buqing Ye5Ying Du6Guangxia Gao7Yong Tian8Lei He9Zusen Fan10Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesKey Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesKey Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesKey Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesKey Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesKey Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesKey Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesKey Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesKey Laboratory of RNA Biology and Beijing Noncoding RNA Laboratory, Institute of Biophysics, Chinese Academy of SciencesDepartment of Hepatobiliary Surgery, PLA General HospitalKey Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesLiver cancer stem cells (CSCs) may contribute to the high rate of recurrence of hepatocellular carcinoma. Here, the authors show that the long coding RNA, LcnBRM, regulates the self-renewal of liver CSCs and tumour initiation through binding to BAF complex thereby activating YAP1.https://doi.org/10.1038/ncomms13608 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Pingping Zhu Yanying Wang Jiayi Wu Guanling Huang Benyu Liu Buqing Ye Ying Du Guangxia Gao Yong Tian Lei He Zusen Fan |
| spellingShingle |
Pingping Zhu Yanying Wang Jiayi Wu Guanling Huang Benyu Liu Buqing Ye Ying Du Guangxia Gao Yong Tian Lei He Zusen Fan LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells Nature Communications |
| author_facet |
Pingping Zhu Yanying Wang Jiayi Wu Guanling Huang Benyu Liu Buqing Ye Ying Du Guangxia Gao Yong Tian Lei He Zusen Fan |
| author_sort |
Pingping Zhu |
| title |
LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells |
| title_short |
LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells |
| title_full |
LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells |
| title_fullStr |
LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells |
| title_full_unstemmed |
LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells |
| title_sort |
lncbrm initiates yap1 signalling activation to drive self-renewal of liver cancer stem cells |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2016-12-01 |
| description |
Liver cancer stem cells (CSCs) may contribute to the high rate of recurrence of hepatocellular carcinoma. Here, the authors show that the long coding RNA, LcnBRM, regulates the self-renewal of liver CSCs and tumour initiation through binding to BAF complex thereby activating YAP1. |
| url |
https://doi.org/10.1038/ncomms13608 |
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