The gut microbiome and irritable bowel syndrome [version 1; referees: 3 approved]

The gut microbiome and irritable bowel syndrome [version 1; referees: 3 approved]

Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders encountered in clinical practice. It is a heterogeneous disorder with a multifactorial pathogenesis. Recent studies have demonstrated that an imbalance in gut bacterial communities, or “dysbiosis”, may be...

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Main Authors: Stacy Menees, William Chey
Format: Article
Language:English
Published: F1000 Research Ltd 2018-07-01
Series:F1000Research
Online Access:https://f1000research.com/articles/7-1029/v1
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spelling doaj-a14c89612c7c486f80ee8b4c01de227d2020-11-25T01:24:08ZengF1000 Research LtdF1000Research2046-14022018-07-01710.12688/f1000research.14592.115879The gut microbiome and irritable bowel syndrome [version 1; referees: 3 approved]Stacy Menees0William Chey1Division of Gastroenterology, Michigan Medicine, 1500 East Medical Center Drive, Ann Arbor, MI 48109-5362, USADivision of Gastroenterology, Michigan Medicine, 1500 East Medical Center Drive, Ann Arbor, MI 48109-5362, USAIrritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders encountered in clinical practice. It is a heterogeneous disorder with a multifactorial pathogenesis. Recent studies have demonstrated that an imbalance in gut bacterial communities, or “dysbiosis”, may be a contributor to the pathophysiology of IBS. There is evidence to suggest that gut dysbiosis may lead to activation of the gut immune system with downstream effects on a variety of other factors of potential relevance to the pathophysiology of IBS. This review will highlight the data addressing the emerging role of the gut microbiome in the pathogenesis of IBS and review the evidence for current and future microbiome based treatmentshttps://f1000research.com/articles/7-1029/v1
collection DOAJ
language English
format Article
sources DOAJ
author Stacy Menees
William Chey
spellingShingle Stacy Menees
William Chey
The gut microbiome and irritable bowel syndrome [version 1; referees: 3 approved]
F1000Research
author_facet Stacy Menees
William Chey
author_sort Stacy Menees
title The gut microbiome and irritable bowel syndrome [version 1; referees: 3 approved]
title_short The gut microbiome and irritable bowel syndrome [version 1; referees: 3 approved]
title_full The gut microbiome and irritable bowel syndrome [version 1; referees: 3 approved]
title_fullStr The gut microbiome and irritable bowel syndrome [version 1; referees: 3 approved]
title_full_unstemmed The gut microbiome and irritable bowel syndrome [version 1; referees: 3 approved]
title_sort gut microbiome and irritable bowel syndrome [version 1; referees: 3 approved]
publisher F1000 Research Ltd
series F1000Research
issn 2046-1402
publishDate 2018-07-01
description Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders encountered in clinical practice. It is a heterogeneous disorder with a multifactorial pathogenesis. Recent studies have demonstrated that an imbalance in gut bacterial communities, or “dysbiosis”, may be a contributor to the pathophysiology of IBS. There is evidence to suggest that gut dysbiosis may lead to activation of the gut immune system with downstream effects on a variety of other factors of potential relevance to the pathophysiology of IBS. This review will highlight the data addressing the emerging role of the gut microbiome in the pathogenesis of IBS and review the evidence for current and future microbiome based treatments
url https://f1000research.com/articles/7-1029/v1
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