Submicron-Sized Nanocomposite Magnetic-Sensitive Carriers: Controllable Organ Distribution and Biological Effects

• Main Authors: Marina V. Novoselova, Sergey V. German, Olga A. Sindeeva, Oleg A. Kulikov, Olga V. Minaeva, Ekaterina P. Brodovskaya, Valentin P. Ageev, Mikhail N. Zharkov, Nikolay A. Pyataev, Gleb B. Sukhorukov, Dmitry A. Gorin
• Format: Article
• Language: English
• Published: MDPI AG 2019-06-01
• Series: Polymers
• Subjects: submicron-sized particles; bovine serum albumin; tannic acid; carriers; magnetic field gradient; magnetite (MNPs); biodistribution; fluorescent imaging
• Online Access: https://www.mdpi.com/2073-4360/11/6/1082

Although new drug delivery systems have been intensely developed in the past decade, no significant increase in the efficiency of drug delivery by nanostructure carriers has been achieved. The reasons are the lack of information about acute toxicity, the influence of the submicron size of the carrier and difficulties with the study of biodistribution in vivo. Here we propose, for the first time in vivo, new nanocomposite submicron carriers made of bovine serum albumin (BSA) and tannic acid (TA) and containing magnetite nanoparticles with sufficient content for navigation in a magnetic field gradient on mice. We examined the efficacy of these submicron carriers as a delivery vehicle in combination with magnetite nanoparticles which were systemically administered intravenously. In addition, the systemic toxicity of this carrier for intravenous administration was explicitly studied. The results showed that (BSA/TA) carriers in the given doses were hemocompatible and didn’t cause any adverse effect on the respiratory system, kidney or liver functions. A combination of gradient-magnetic-field controllable biodistribution of submicron carriers with fluorescence tomography/MRI imaging in vivo provides a new opportunity to improve drug delivery efficiency.