The role of heparanase and sulfatases in the modification of heparan sulfate proteoglycans within the tumour microenvironment and opportunities for novel cancer therapeutics

The role of heparanase and sulfatases in the modification of heparan sulfate proteoglycans within the tumour microenvironment and opportunities for novel cancer therapeutics

Heparan sulfate proteoglycans (HSPGs) are an integral and dynamic part of normal tissue architecture at the cell surface and within the extracellular matrix (ECM). The modification of HSPGs in the tumour microenvironment is known to result not just in structural but also functional consequences whic...

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Bibliographic Details
Main Authors: Edward eHammond, Ashwani eKhurana, Viji eShridhar, Keith eDredge
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-07-01
Series:Frontiers in Oncology
Subjects:
cancer therapy
Heparan sulfate
Heparanase
tumor microenvironment targeting
SULF1
Sulf2
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00195/full

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