PEGylated graphene oxide elicits strong immunological responses despite surface passivation

Polyethylene glycol has been widely utilized to functionalize nanomaterials in order to improve their biocompatibility. Here, the authors demonstrate that PEGylated nano-graphene oxide can elicit an inflammatory response, contradicting current literature.

Bibliographic Details
Main Authors:	Nana Luo, Jeffrey K. Weber, Shuang Wang, Binquan Luan, Hua Yue, Xiaobo Xi, Jing Du, Zaixing Yang, Wei Wei, Ruhong Zhou, Guanghui Ma
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms14537

id	doaj-a128b2d6b00b4f8f896db220436e5a4a
record_format	Article
spelling	doaj-a128b2d6b00b4f8f896db220436e5a4a2021-05-11T07:29:22ZengNature Publishing GroupNature Communications2041-17232017-02-018111010.1038/ncomms14537PEGylated graphene oxide elicits strong immunological responses despite surface passivationNana Luo0Jeffrey K. Weber1Shuang Wang2Binquan Luan3Hua Yue4Xiaobo Xi5Jing Du6Zaixing Yang7Wei Wei8Ruhong Zhou9Guanghui Ma10State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of SciencesComputational Biology Center, IBM Thomas J. Watson Research CenterState Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of SciencesComputational Biology Center, IBM Thomas J. Watson Research CenterState Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of SciencesState Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of SciencesDepartment of Engineering Mechanics, Institute of Biomechanics and Medical Engineering, Tsinghua UniversityInstitute of Quantitative Biology and Medicine, SRMP and RAD-X, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow UniversityState Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of SciencesComputational Biology Center, IBM Thomas J. Watson Research CenterState Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of SciencesPolyethylene glycol has been widely utilized to functionalize nanomaterials in order to improve their biocompatibility. Here, the authors demonstrate that PEGylated nano-graphene oxide can elicit an inflammatory response, contradicting current literature.https://doi.org/10.1038/ncomms14537
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Nana Luo Jeffrey K. Weber Shuang Wang Binquan Luan Hua Yue Xiaobo Xi Jing Du Zaixing Yang Wei Wei Ruhong Zhou Guanghui Ma
spellingShingle	Nana Luo Jeffrey K. Weber Shuang Wang Binquan Luan Hua Yue Xiaobo Xi Jing Du Zaixing Yang Wei Wei Ruhong Zhou Guanghui Ma PEGylated graphene oxide elicits strong immunological responses despite surface passivation Nature Communications
author_facet	Nana Luo Jeffrey K. Weber Shuang Wang Binquan Luan Hua Yue Xiaobo Xi Jing Du Zaixing Yang Wei Wei Ruhong Zhou Guanghui Ma
author_sort	Nana Luo
title	PEGylated graphene oxide elicits strong immunological responses despite surface passivation
title_short	PEGylated graphene oxide elicits strong immunological responses despite surface passivation
title_full	PEGylated graphene oxide elicits strong immunological responses despite surface passivation
title_fullStr	PEGylated graphene oxide elicits strong immunological responses despite surface passivation
title_full_unstemmed	PEGylated graphene oxide elicits strong immunological responses despite surface passivation
title_sort	pegylated graphene oxide elicits strong immunological responses despite surface passivation
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-02-01
description	Polyethylene glycol has been widely utilized to functionalize nanomaterials in order to improve their biocompatibility. Here, the authors demonstrate that PEGylated nano-graphene oxide can elicit an inflammatory response, contradicting current literature.
url	https://doi.org/10.1038/ncomms14537
work_keys_str_mv	AT nanaluo pegylatedgrapheneoxideelicitsstrongimmunologicalresponsesdespitesurfacepassivation AT jeffreykweber pegylatedgrapheneoxideelicitsstrongimmunologicalresponsesdespitesurfacepassivation AT shuangwang pegylatedgrapheneoxideelicitsstrongimmunologicalresponsesdespitesurfacepassivation AT binquanluan pegylatedgrapheneoxideelicitsstrongimmunologicalresponsesdespitesurfacepassivation AT huayue pegylatedgrapheneoxideelicitsstrongimmunologicalresponsesdespitesurfacepassivation AT xiaoboxi pegylatedgrapheneoxideelicitsstrongimmunologicalresponsesdespitesurfacepassivation AT jingdu pegylatedgrapheneoxideelicitsstrongimmunologicalresponsesdespitesurfacepassivation AT zaixingyang pegylatedgrapheneoxideelicitsstrongimmunologicalresponsesdespitesurfacepassivation AT weiwei pegylatedgrapheneoxideelicitsstrongimmunologicalresponsesdespitesurfacepassivation AT ruhongzhou pegylatedgrapheneoxideelicitsstrongimmunologicalresponsesdespitesurfacepassivation AT guanghuima pegylatedgrapheneoxideelicitsstrongimmunologicalresponsesdespitesurfacepassivation
_version_	1721452156400173056

PEGylated graphene oxide elicits strong immunological responses despite surface passivation

Similar Items