Nitrate and Nitrite Promote Formation of Tobacco-Specific Nitrosamines via Nitrogen Oxides Intermediates during Postcured Storage under Warm Temperature

Nitrate and Nitrite Promote Formation of Tobacco-Specific Nitrosamines via Nitrogen Oxides Intermediates during Postcured Storage under Warm Temperature

Tobacco-specific nitrosamines (TSNAs) are carcinogenic and are present in cured tobacco leaves. This study was designed to elucidate the mechanisms of TSNAs formation under warm temperature storage conditions. Results showed that nitrogen oxides (NOx) were produced from nitrate and nitrite in a shor...

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Main Authors: Jun Wang, Huijuan Yang, Hongzhi Shi, Jun Zhou, Ruoshi Bai, Mengyue Zhang, Tong Jin
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2017/6135215
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spelling doaj-a11e0b3d14a440bc99aa4fe6843acec52020-11-24T22:41:37ZengHindawi LimitedJournal of Chemistry2090-90632090-90712017-01-01201710.1155/2017/61352156135215Nitrate and Nitrite Promote Formation of Tobacco-Specific Nitrosamines via Nitrogen Oxides Intermediates during Postcured Storage under Warm TemperatureJun Wang0Huijuan Yang1Hongzhi Shi2Jun Zhou3Ruoshi Bai4Mengyue Zhang5Tong Jin6Henan Agricultural University, National Tobacco Cultivation & Physiology & Biochemistry Research Center, Zhengzhou 450002, ChinaHenan Agricultural University, National Tobacco Cultivation & Physiology & Biochemistry Research Center, Zhengzhou 450002, ChinaHenan Agricultural University, National Tobacco Cultivation & Physiology & Biochemistry Research Center, Zhengzhou 450002, ChinaBeijing Cigarette Factory, Shanghai Tobacco Group Co. Ltd., Beijing 100024, ChinaBeijing Cigarette Factory, Shanghai Tobacco Group Co. Ltd., Beijing 100024, ChinaHenan Agricultural University, National Tobacco Cultivation & Physiology & Biochemistry Research Center, Zhengzhou 450002, ChinaHenan Agricultural University, National Tobacco Cultivation & Physiology & Biochemistry Research Center, Zhengzhou 450002, ChinaTobacco-specific nitrosamines (TSNAs) are carcinogenic and are present in cured tobacco leaves. This study was designed to elucidate the mechanisms of TSNAs formation under warm temperature storage conditions. Results showed that nitrogen oxides (NOx) were produced from nitrate and nitrite in a short period of time under 45°C and then reacted with alkaloids to form TSNAs. Nitrite was more effective than nitrate in promoting TSNAs formation during 45°C storage which may be due to the fact that nitrite can produce a large amount of NOx in comparison with nitrate. Presence of activated carbon effectively inhibited the TSNAs formation because of the adsorption of NOx on the activated carbon. The results indicated that TSNAs are derived from a gas/solid phase nitrosation reaction between NOx and alkaloids. Nitrate and nitrite are major contributors to the formation of TSNAs during warm temperature storage of tobacco.http://dx.doi.org/10.1155/2017/6135215
collection DOAJ
language English
format Article
sources DOAJ
author Jun Wang
Huijuan Yang
Hongzhi Shi
Jun Zhou
Ruoshi Bai
Mengyue Zhang
Tong Jin
spellingShingle Jun Wang
Huijuan Yang
Hongzhi Shi
Jun Zhou
Ruoshi Bai
Mengyue Zhang
Tong Jin
Nitrate and Nitrite Promote Formation of Tobacco-Specific Nitrosamines via Nitrogen Oxides Intermediates during Postcured Storage under Warm Temperature
Journal of Chemistry
author_facet Jun Wang
Huijuan Yang
Hongzhi Shi
Jun Zhou
Ruoshi Bai
Mengyue Zhang
Tong Jin
author_sort Jun Wang
title Nitrate and Nitrite Promote Formation of Tobacco-Specific Nitrosamines via Nitrogen Oxides Intermediates during Postcured Storage under Warm Temperature
title_short Nitrate and Nitrite Promote Formation of Tobacco-Specific Nitrosamines via Nitrogen Oxides Intermediates during Postcured Storage under Warm Temperature
title_full Nitrate and Nitrite Promote Formation of Tobacco-Specific Nitrosamines via Nitrogen Oxides Intermediates during Postcured Storage under Warm Temperature
title_fullStr Nitrate and Nitrite Promote Formation of Tobacco-Specific Nitrosamines via Nitrogen Oxides Intermediates during Postcured Storage under Warm Temperature
title_full_unstemmed Nitrate and Nitrite Promote Formation of Tobacco-Specific Nitrosamines via Nitrogen Oxides Intermediates during Postcured Storage under Warm Temperature
title_sort nitrate and nitrite promote formation of tobacco-specific nitrosamines via nitrogen oxides intermediates during postcured storage under warm temperature
publisher Hindawi Limited
series Journal of Chemistry
issn 2090-9063
2090-9071
publishDate 2017-01-01
description Tobacco-specific nitrosamines (TSNAs) are carcinogenic and are present in cured tobacco leaves. This study was designed to elucidate the mechanisms of TSNAs formation under warm temperature storage conditions. Results showed that nitrogen oxides (NOx) were produced from nitrate and nitrite in a short period of time under 45°C and then reacted with alkaloids to form TSNAs. Nitrite was more effective than nitrate in promoting TSNAs formation during 45°C storage which may be due to the fact that nitrite can produce a large amount of NOx in comparison with nitrate. Presence of activated carbon effectively inhibited the TSNAs formation because of the adsorption of NOx on the activated carbon. The results indicated that TSNAs are derived from a gas/solid phase nitrosation reaction between NOx and alkaloids. Nitrate and nitrite are major contributors to the formation of TSNAs during warm temperature storage of tobacco.
url http://dx.doi.org/10.1155/2017/6135215
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AT huijuanyang nitrateandnitritepromoteformationoftobaccospecificnitrosaminesvianitrogenoxidesintermediatesduringpostcuredstorageunderwarmtemperature
AT hongzhishi nitrateandnitritepromoteformationoftobaccospecificnitrosaminesvianitrogenoxidesintermediatesduringpostcuredstorageunderwarmtemperature
AT junzhou nitrateandnitritepromoteformationoftobaccospecificnitrosaminesvianitrogenoxidesintermediatesduringpostcuredstorageunderwarmtemperature
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AT mengyuezhang nitrateandnitritepromoteformationoftobaccospecificnitrosaminesvianitrogenoxidesintermediatesduringpostcuredstorageunderwarmtemperature
AT tongjin nitrateandnitritepromoteformationoftobaccospecificnitrosaminesvianitrogenoxidesintermediatesduringpostcuredstorageunderwarmtemperature
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