A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs
Chikungunya virus is a mosquito transmitted untreatable emergent pathogen that causes joint pain and fever. Here the authors perform a host genome-wide loss-of-function screen to identify targets for chikungunya antiviral drugs and validate hits using a mouse model of chikungunya infection.
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| Language: | English |
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Nature Publishing Group
2016-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms11320 |
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doaj-a11a26eb638c455b881f87794f4e9c132021-05-11T10:38:34ZengNature Publishing GroupNature Communications2041-17232016-05-017111410.1038/ncomms11320A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugsAlexander Karlas0Stefano Berre1Thérèse Couderc2Margus Varjak3Peter Braun4Michael Meyer5Nicolas Gangneux6Liis Karo-Astover7Friderike Weege8Martin Raftery9Günther Schönrich10Uwe Klemm11Anne Wurzlbauer12Franz Bracher13Andres Merits14Thomas F. Meyer15Marc Lecuit16Department of Molecular Biology, Max Planck Institute for Infection BiologyInstitut Pasteur, Biology of Infection UnitInstitut Pasteur, Biology of Infection UnitInstitute of Technology, University of TartuDepartment of Molecular Biology, Max Planck Institute for Infection BiologySteinbeis Innovation gGmbH, Center for Systems BiomedicineInstitut Pasteur, Biology of Infection UnitInstitute of Technology, University of TartuDepartment of Molecular Biology, Max Planck Institute for Infection BiologyInstitute of Virology, Charité University MedicineInstitute of Virology, Charité University MedicineMax Planck Institute for Infection Biology, Core Facility Experimental AnimalsDepartment of Pharmacy-Center for Drug Research, Ludwig-Maximilians-UniversityDepartment of Pharmacy-Center for Drug Research, Ludwig-Maximilians-UniversityInstitute of Technology, University of TartuDepartment of Molecular Biology, Max Planck Institute for Infection BiologyInstitut Pasteur, Biology of Infection UnitChikungunya virus is a mosquito transmitted untreatable emergent pathogen that causes joint pain and fever. Here the authors perform a host genome-wide loss-of-function screen to identify targets for chikungunya antiviral drugs and validate hits using a mouse model of chikungunya infection.https://doi.org/10.1038/ncomms11320 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Alexander Karlas Stefano Berre Thérèse Couderc Margus Varjak Peter Braun Michael Meyer Nicolas Gangneux Liis Karo-Astover Friderike Weege Martin Raftery Günther Schönrich Uwe Klemm Anne Wurzlbauer Franz Bracher Andres Merits Thomas F. Meyer Marc Lecuit |
| spellingShingle |
Alexander Karlas Stefano Berre Thérèse Couderc Margus Varjak Peter Braun Michael Meyer Nicolas Gangneux Liis Karo-Astover Friderike Weege Martin Raftery Günther Schönrich Uwe Klemm Anne Wurzlbauer Franz Bracher Andres Merits Thomas F. Meyer Marc Lecuit A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs Nature Communications |
| author_facet |
Alexander Karlas Stefano Berre Thérèse Couderc Margus Varjak Peter Braun Michael Meyer Nicolas Gangneux Liis Karo-Astover Friderike Weege Martin Raftery Günther Schönrich Uwe Klemm Anne Wurzlbauer Franz Bracher Andres Merits Thomas F. Meyer Marc Lecuit |
| author_sort |
Alexander Karlas |
| title |
A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs |
| title_short |
A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs |
| title_full |
A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs |
| title_fullStr |
A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs |
| title_full_unstemmed |
A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs |
| title_sort |
human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2016-05-01 |
| description |
Chikungunya virus is a mosquito transmitted untreatable emergent pathogen that causes joint pain and fever. Here the authors perform a host genome-wide loss-of-function screen to identify targets for chikungunya antiviral drugs and validate hits using a mouse model of chikungunya infection. |
| url |
https://doi.org/10.1038/ncomms11320 |
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