Protective Effects of N-Acetylcysteine in Concanavalin A-Induced Hepatitis in Mice
This study was designed to study the protective effects and mechanisms of N-acetylcysteine (NAC) in concanavalin A-induced hepatitis in mice. In this study, pretreatment with NAC ameliorated the histopathological changes and suppressed inflammatory cytokines in ConA-induced hepatitis. The expression...
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Hindawi Limited
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/189785 |
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doaj-a117c3374fa94e15a10bbc2a239974c62020-11-24T21:00:02ZengHindawi LimitedMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/189785189785Protective Effects of N-Acetylcysteine in Concanavalin A-Induced Hepatitis in MiceChengfen Wang0Yujing Xia1Yuanyuan Zheng2Weiqi Dai3Fan Wang4Kan Chen5Jingjing Li6Sainan Li7Rong Zhu8Jing Yang9Qin Yin10Huawei Zhang11Junshan Wang12Jie Lu13Yingqun Zhou14Chuanyong Guo15Department of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University of Medicine, Shanghai 200072, ChinaDepartment of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University of Medicine, Shanghai 200072, ChinaDepartment of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University of Medicine, Shanghai 200072, ChinaDepartment of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University of Medicine, Shanghai 200072, ChinaDepartment of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University of Medicine, Shanghai 200072, ChinaDepartment of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University of Medicine, Shanghai 200072, ChinaDepartment of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University of Medicine, Shanghai 200072, ChinaDepartment of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University of Medicine, Shanghai 200072, ChinaDepartment of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University of Medicine, Shanghai 200072, ChinaDepartment of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University of Medicine, Shanghai 200072, ChinaDepartment of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University of Medicine, Shanghai 200072, ChinaDepartment of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University of Medicine, Shanghai 200072, ChinaDepartment of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University of Medicine, Shanghai 200072, ChinaDepartment of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University of Medicine, Shanghai 200072, ChinaDepartment of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University of Medicine, Shanghai 200072, ChinaDepartment of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University of Medicine, Shanghai 200072, ChinaThis study was designed to study the protective effects and mechanisms of N-acetylcysteine (NAC) in concanavalin A-induced hepatitis in mice. In this study, pretreatment with NAC ameliorated the histopathological changes and suppressed inflammatory cytokines in ConA-induced hepatitis. The expression of IL-2, IL-6, TNF-α, and IFN-γ was significantly reduced in the NAC-treated groups. NAC activated PI3K/Akt pathway and inhibited the activation of NF-κB. Additionally, NAC reduced autophagosome formation, as assessed by detecting the expression of LC3 and Beclin 1. Our results demonstrate that NAC can alleviate ConA-induced hepatitis by regulating the PI3K/Akt pathway and reducing the late stages of autophagy. Our results described a new pharmaceutical to provide more effective therapies for immune hepatitis.http://dx.doi.org/10.1155/2015/189785 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Chengfen Wang Yujing Xia Yuanyuan Zheng Weiqi Dai Fan Wang Kan Chen Jingjing Li Sainan Li Rong Zhu Jing Yang Qin Yin Huawei Zhang Junshan Wang Jie Lu Yingqun Zhou Chuanyong Guo |
| spellingShingle |
Chengfen Wang Yujing Xia Yuanyuan Zheng Weiqi Dai Fan Wang Kan Chen Jingjing Li Sainan Li Rong Zhu Jing Yang Qin Yin Huawei Zhang Junshan Wang Jie Lu Yingqun Zhou Chuanyong Guo Protective Effects of N-Acetylcysteine in Concanavalin A-Induced Hepatitis in Mice Mediators of Inflammation |
| author_facet |
Chengfen Wang Yujing Xia Yuanyuan Zheng Weiqi Dai Fan Wang Kan Chen Jingjing Li Sainan Li Rong Zhu Jing Yang Qin Yin Huawei Zhang Junshan Wang Jie Lu Yingqun Zhou Chuanyong Guo |
| author_sort |
Chengfen Wang |
| title |
Protective Effects of N-Acetylcysteine in Concanavalin A-Induced Hepatitis in Mice |
| title_short |
Protective Effects of N-Acetylcysteine in Concanavalin A-Induced Hepatitis in Mice |
| title_full |
Protective Effects of N-Acetylcysteine in Concanavalin A-Induced Hepatitis in Mice |
| title_fullStr |
Protective Effects of N-Acetylcysteine in Concanavalin A-Induced Hepatitis in Mice |
| title_full_unstemmed |
Protective Effects of N-Acetylcysteine in Concanavalin A-Induced Hepatitis in Mice |
| title_sort |
protective effects of n-acetylcysteine in concanavalin a-induced hepatitis in mice |
| publisher |
Hindawi Limited |
| series |
Mediators of Inflammation |
| issn |
0962-9351 1466-1861 |
| publishDate |
2015-01-01 |
| description |
This study was designed to study the protective effects and mechanisms of N-acetylcysteine (NAC) in concanavalin A-induced hepatitis in mice. In this study, pretreatment with NAC ameliorated the histopathological changes and suppressed inflammatory cytokines in ConA-induced hepatitis. The expression of IL-2, IL-6, TNF-α, and IFN-γ was significantly reduced in the NAC-treated groups. NAC activated PI3K/Akt pathway and inhibited the activation of NF-κB. Additionally, NAC reduced autophagosome formation, as assessed by detecting the expression of LC3 and Beclin 1. Our results demonstrate that NAC can alleviate ConA-induced hepatitis by regulating the PI3K/Akt pathway and reducing the late stages of autophagy. Our results described a new pharmaceutical to provide more effective therapies for immune hepatitis. |
| url |
http://dx.doi.org/10.1155/2015/189785 |
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