Novel coumarins active against Trypanosoma cruzi and toxicity assessment using the animal model Caenorhabditis elegans

Novel coumarins active against Trypanosoma cruzi and toxicity assessment using the animal model Caenorhabditis elegans

Abstract Background Chagas disease (CD) is a tropical parasitic disease. Although the number of people infected is very high, the only drugs available to treat CD, nifurtimox (Nfx) and benznidazole, are highly toxic, particularly in the chronic stage of the disease. Coumarins are a large class of co...

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Main Authors: Fabiana Gomes Nascimento Soares, Gabriela Göethel, Luciano Porto Kagami, Gustavo Machado das Neves, Elisa Sauer, Estefania Birriel, Javier Varela, Itamar Luís Gonçalves, Gilsane Von Poser, Mercedes González, Daniel Fábio Kawano, Fávero Reisdorfer Paula, Eduardo Borges de Melo, Solange Cristina Garcia, Hugo Cerecetto, Vera Lucia Eifler-Lima
Format: Article
Language:English
Published: BMC 2019-12-01
Series:BMC Pharmacology and Toxicology
Subjects:
Caenorhabditis elegans
Trypanosoma cruzi
Coumarins
Chagas disease
Structure-activity relationship
Online Access:https://doi.org/10.1186/s40360-019-0357-z

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