SCFβ‐TrCP ubiquitinates CHK1 in an AMPK‐dependent manner in response to glucose deprivation

SCFβ‐TrCP ubiquitinates CHK1 in an AMPK‐dependent manner in response to glucose deprivation

The ATR/CHK1 pathway is a key effector of cellular response to DNA damage and therefore is a critical regulator of genomic stability. While the ATR/CHK1 pathway is often inactivated by mutations, CHK1 itself is rarely mutated in human cancers. Thus, cellular levels of CHK1 likely play a key role in...

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Bibliographic Details
Main Authors: Ying Ma, Danrui Cui, Xiufang Xiong, Hiroyuki Inuzuka, Wenyi Wei, Yi Sun, Brian J. North, Yongchao Zhao
Format: Article
Language:English
Published: Wiley 2019-02-01
Series:Molecular Oncology
Subjects:
AMPK
CHK1
glucose deprivation
ubiquitination
β‐TrCP
Online Access:https://doi.org/10.1002/1878-0261.12403

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