A pH-responsive drug delivery matrix from an interpolyelectrolyte complex: preparation and pharmacotechnical properties

• Main Authors: Jorge Andrés Montaña, León Darío Perez, Yolima Baena
• Format: Article
• Language: English
• Published: Universidade de São Paulo 2018-07-01
• Series: Brazilian Journal of Pharmaceutical Sciences
• Subjects: Interpolyelectrolyte complex; Pharmacotechnical properties; Dexibuprofen; Controlled release; Hydrophillic matrix.
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200620&lng=en&tlng=en

ABSTRACT Interpolyelectrolyte complexes, which constitute a type of polymeric material obtained through the self-assembly of oppositely charged polymers, exhibit interesting properties for use in the design of smart matrices for drug delivery. In the present study, a stoichiometric interpolyelectrolyte complex (SIPEC) composed of Eudragit E® and Eudragit® L100 was obtained at pH 6.0 and characterized and evaluated as a hydrophilic matrix for dexibuprofen. The formation of a SIPEC was monitored by ζ-potential measurements and characterized using infrared spectroscopy, thermal analysis, and scanning electron microscopy. The results indicated that a SIPEC obtained under these conditions can be used as a matrix for controlling the release of dexibuprofen and exhibit a pH-triggered release.