Hypericin-photodynamic therapy inhibits the growth of adult T-cell leukemia cells through induction of apoptosis and suppression of viral transcription

Hypericin-photodynamic therapy inhibits the growth of adult T-cell leukemia cells through induction of apoptosis and suppression of viral transcription

Abstract Background Adult T-cell leukemia (ATL) is an aggressive neoplasm caused by human T-cell leukemia virus type 1 (HTLV-1). ATL carries a poor prognosis due to chemotherapy resistance. Thus, it is urgent to develop new treatment strategies. Hypericin (HY) is a new-type of photosensitizer in the...

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Bibliographic Details
Main Authors: Lingling Xu, Xueqing Zhang, Wenzhao Cheng, Yong Wang, Kaining Yi, Zhilong Wang, Yiling Zhang, Linxiang Shao, Tiejun Zhao
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Retrovirology
Subjects:
Hypericin
Photodynamic therapy
HTLV-1
ATL
Apoptosis
Online Access:http://link.springer.com/article/10.1186/s12977-019-0467-0

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