Saponins from edible spears of wild asparagus inhibit AKT, p70S6K, and ERK signalling, and induce apoptosis through G0/G1 cell cycle arrest in human colon cancer HCT-116 cells

Saponins from edible spears of wild asparagus inhibit AKT, p70S6K, and ERK signalling, and induce apoptosis through G0/G1 cell cycle arrest in human colon cancer HCT-116 cells

The effects of steroidal saponins from edible spears of wild triguero Huetor-Tajar asparagus on some of the oncogenic molecular pathways that are affected in human colon cancer cells were investigated. Reverse-phase chromatography and a new HPLC-MS method were used to respectively isolate and analys...

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Bibliographic Details
Main Authors: Sara Jaramillo, Francisco J.G. Muriana, Rafael Guillen, Ana Jimenez-Araujo, Rocio Rodriguez-Arcos, Sergio Lopez
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Journal of Functional Foods
Subjects:
Apoptosis
Asparagus
Cell cycle
Colon cancer
Human
Saponins
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464616301852

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