The AT1 Receptor Antagonist Losartan Does Not Affect Depressive-Like State and Memory Impairment Evoked by Chronic Stressors in Rats

The AT1 Receptor Antagonist Losartan Does Not Affect Depressive-Like State and Memory Impairment Evoked by Chronic Stressors in Rats

The present study investigated the effect of the treatment with the angiotensin II type 1 receptor (AT1) antagonist losartan in the depressive-like state and memory impairment evoked by exposure to either homotypic (i.e., repeated exposure to the same type of stressor) or heterotypic (i.e., exposure...

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Bibliographic Details
Main Authors: Willian Costa-Ferreira, Gessynger Morais-Silva, Lucas Gomes-de-Souza, Marcelo T. Marin, Carlos C. Crestani
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Pharmacology
Subjects:
losartan
depression
locomotion
anhedonia
memory
restraint stress
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00705/full

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