The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat

The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat

Human positive transcription elongation factor b (P-TEFb) phosphorylates RNA polymerase II and regulatory proteins to trigger elongation of many gene transcripts. The HIV-1 Tat protein selectively recruits P-TEFb as part of a super elongation complex (SEC) organized on a flexible AFF1 or AFF4 scaffo...

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Bibliographic Details
Main Authors: Ursula Schulze-Gahmen, Heather Upton, Andrew Birnberg, Katherine Bao, Seemay Chou, Nevan J Krogan, Qiang Zhou, Tom Alber
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-03-01
Series:eLife
Subjects:
transcription elongation
super elongation complex
SEC
intrinsically disordered protein
Online Access:https://elifesciences.org/articles/00327

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