Teraphtal (sodium salt of cobalt 4,5-carboxyphthalocyanine) Decreases Sensitivity of Tumor Cells to Anthracycline Antibiotics and Mitoxantrone in Vitro

Teraphtal (sodium salt of cobalt 4,5-carboxyphthalocyanine) Decreases Sensitivity of Tumor Cells to Anthracycline Antibiotics and Mitoxantrone in Vitro

Background. Anthracycline antibiotics (AA) are widely used in clinical oncohematology. As is well known АА cytotoxicity diminishes in the presence of hemin (FePPIX), an endogenous metalloporphyrine. Aim. To study effect of teraphtal (TPh) and its structural analog FePPIX on cytotoxicity of “anthr...

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Bibliographic Details
Main Authors: TA Sidorova, OO Ryabaya, VV Tatarskii, DA Khochenkov, ES Ivanova, OL Kaliya
Format: Article
Language:Russian
Published: Practical Medicine Publishing House 2018-01-01
Series:Kliničeskaâ onkogematologiâ
Subjects:
anthracycline antibiotics
mitoxantrone
teraphtal
hemin
human tumor cells
drug induced senescence
autophagy
Online Access:http://bloodjournal.ru/wp-content/uploads/2018/01/2-1.pdf

Internet

http://bloodjournal.ru/wp-content/uploads/2018/01/2-1.pdf

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