Gradient phenomenon of multidrug resistance gene expression in breast cancer during neoadjuvant chemotherapy is related to disease progression

Gradient phenomenon of multidrug resistance gene expression in breast cancer during neoadjuvant chemotherapy is related to disease progression

The paper examined 106 patients with breast cancer (BC) treated with neoadjuvant chemotherapy (NАС). In the biopsy material, derived from primary tumor before NAC and surgical samples after chemotherapy the expression of 8 multidrug resistance genes (MDR) ABCB1, АВСВ2, ABCC1, ABCC2, АВСС5, ABCG1, AB...

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Bibliographic Details
Main Author: N. V. Litviakov
Format: Article
Language:Russian
Published: Tomsk National Research Medical Center of the Russian Academy of Sciences 2016-02-01
Series:Sibirskij Onkologičeskij Žurnal
Subjects:
ent phenomenon is the marker indicating the presence of a balanced system of gene regulation and tumor cell response to chemotherapy. practically
the estimation of the effectiveness of preoperative chemotherapy along with a change in mdr gene expression during nac could significantly improve prediction of disease outcome in patients with breast cancer
Online Access:https://www.siboncoj.ru/jour/article/view/162

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