Preparation and Characterization of Perforated SERS Active Array for Particle Trapping and Sensitive Molecular Analysis

Preparation and Characterization of Perforated SERS Active Array for Particle Trapping and Sensitive Molecular Analysis

A gold-coated array of flow-through inverse pyramids applicable as substrate for entrapment and immobilization of micro-objects and for surface enhanced Raman spectroscopic measurements was fabricated using bulk micromachining techniques from silicon. Surface morphology, optical reflectance, immobil...

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Main Authors: István Rigó, Miklós Veres, Tamás Váczi, Eszter Holczer, Orsolya Hakkel, András Deák, Péter Fürjes
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Biosensors
Subjects:
surface enhanced Raman spectroscopy
SERS array
bulk micromachining
particle/cell entrapment
FDTD
Online Access:https://www.mdpi.com/2079-6374/9/3/93
id doaj-a0d1c04bd9094d8c91e77859157b1a65
record_format Article
spelling doaj-a0d1c04bd9094d8c91e77859157b1a652020-11-25T01:53:24ZengMDPI AGBiosensors2079-63742019-07-01939310.3390/bios9030093bios9030093Preparation and Characterization of Perforated SERS Active Array for Particle Trapping and Sensitive Molecular AnalysisIstván Rigó0Miklós Veres1Tamás Váczi2Eszter Holczer3Orsolya Hakkel4András Deák5Péter Fürjes6Institute for Solid State Physics and Optics, Wigner Research Centre for Physics, Konkoly-Thege Miklós út 29–33., HAS, 1121 Budapest, HungaryInstitute for Solid State Physics and Optics, Wigner Research Centre for Physics, Konkoly-Thege Miklós út 29–33., HAS, 1121 Budapest, HungaryInstitute for Solid State Physics and Optics, Wigner Research Centre for Physics, Konkoly-Thege Miklós út 29–33., HAS, 1121 Budapest, HungaryInstitute of Technical Physics and Materials Science, Centre for Energy Research, Konkoly-Thege Miklós út 29–33., HAS, 1121 Budapest, HungaryInstitute of Technical Physics and Materials Science, Centre for Energy Research, Konkoly-Thege Miklós út 29–33., HAS, 1121 Budapest, HungaryInstitute of Technical Physics and Materials Science, Centre for Energy Research, Konkoly-Thege Miklós út 29–33., HAS, 1121 Budapest, HungaryInstitute of Technical Physics and Materials Science, Centre for Energy Research, Konkoly-Thege Miklós út 29–33., HAS, 1121 Budapest, HungaryA gold-coated array of flow-through inverse pyramids applicable as substrate for entrapment and immobilization of micro-objects and for surface enhanced Raman spectroscopic measurements was fabricated using bulk micromachining techniques from silicon. Surface morphology, optical reflectance, immobilization properties, and surface enhanced Raman amplification of the array were modelled and characterized. It was found that the special perforated periodic 3D structure can be used for parallel particle and cell trapping and highly sensitive molecular analysis of the immobilized objects.https://www.mdpi.com/2079-6374/9/3/93surface enhanced Raman spectroscopySERS arraybulk micromachiningparticle/cell entrapmentFDTD
collection DOAJ
language English
format Article
sources DOAJ
author István Rigó
Miklós Veres
Tamás Váczi
Eszter Holczer
Orsolya Hakkel
András Deák
Péter Fürjes
spellingShingle István Rigó
Miklós Veres
Tamás Váczi
Eszter Holczer
Orsolya Hakkel
András Deák
Péter Fürjes
Preparation and Characterization of Perforated SERS Active Array for Particle Trapping and Sensitive Molecular Analysis
Biosensors
surface enhanced Raman spectroscopy
SERS array
bulk micromachining
particle/cell entrapment
FDTD
author_facet István Rigó
Miklós Veres
Tamás Váczi
Eszter Holczer
Orsolya Hakkel
András Deák
Péter Fürjes
author_sort István Rigó
title Preparation and Characterization of Perforated SERS Active Array for Particle Trapping and Sensitive Molecular Analysis
title_short Preparation and Characterization of Perforated SERS Active Array for Particle Trapping and Sensitive Molecular Analysis
title_full Preparation and Characterization of Perforated SERS Active Array for Particle Trapping and Sensitive Molecular Analysis
title_fullStr Preparation and Characterization of Perforated SERS Active Array for Particle Trapping and Sensitive Molecular Analysis
title_full_unstemmed Preparation and Characterization of Perforated SERS Active Array for Particle Trapping and Sensitive Molecular Analysis
title_sort preparation and characterization of perforated sers active array for particle trapping and sensitive molecular analysis
publisher MDPI AG
series Biosensors
issn 2079-6374
publishDate 2019-07-01
description A gold-coated array of flow-through inverse pyramids applicable as substrate for entrapment and immobilization of micro-objects and for surface enhanced Raman spectroscopic measurements was fabricated using bulk micromachining techniques from silicon. Surface morphology, optical reflectance, immobilization properties, and surface enhanced Raman amplification of the array were modelled and characterized. It was found that the special perforated periodic 3D structure can be used for parallel particle and cell trapping and highly sensitive molecular analysis of the immobilized objects.
topic surface enhanced Raman spectroscopy
SERS array
bulk micromachining
particle/cell entrapment
FDTD
url https://www.mdpi.com/2079-6374/9/3/93
work_keys_str_mv AT istvanrigo preparationandcharacterizationofperforatedsersactivearrayforparticletrappingandsensitivemolecularanalysis
AT miklosveres preparationandcharacterizationofperforatedsersactivearrayforparticletrappingandsensitivemolecularanalysis
AT tamasvaczi preparationandcharacterizationofperforatedsersactivearrayforparticletrappingandsensitivemolecularanalysis
AT eszterholczer preparationandcharacterizationofperforatedsersactivearrayforparticletrappingandsensitivemolecularanalysis
AT orsolyahakkel preparationandcharacterizationofperforatedsersactivearrayforparticletrappingandsensitivemolecularanalysis
AT andrasdeak preparationandcharacterizationofperforatedsersactivearrayforparticletrappingandsensitivemolecularanalysis
AT peterfurjes preparationandcharacterizationofperforatedsersactivearrayforparticletrappingandsensitivemolecularanalysis
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