Deuterium Oxide (D<sub>2</sub>O) Induces Early Stress Response Gene Expression and Impairs Growth and Metastasis of Experimental Malignant Melanoma

Deuterium Oxide (D<sub>2</sub>O) Induces Early Stress Response Gene Expression and Impairs Growth and Metastasis of Experimental Malignant Melanoma

There are two stable isotopes of hydrogen, protium (<sup>1</sup>H) and deuterium (<sup>2</sup>H; D). Cellular stress response dysregulation in cancer represents both a major pathological driving force and a promising therapeutic target, but the molecular consequences and pote...

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Bibliographic Details
Main Authors: Jana Jandova, Anh B. Hua, Jocelyn Fimbres, Georg T. Wondrak
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cancers
Subjects:
malignant melanoma
deuterium oxide
heavy water
SCID mouse metastasis model
A375 melanoma xenograft model
cellular stress response
Online Access:https://www.mdpi.com/2072-6694/13/4/605

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