Potential of ultra-high-resolution photon-counting CT of bone metastases: initial experiences in breast cancer patients

• Main Authors: E. Wehrse, S. Sawall, L. Klein, P. Glemser, S. Delorme, H.-P. Schlemmer, M. Kachelrieß, M. Uhrig, C. H. Ziener, L. T. Rotkopf
• Format: Article
• Language: English
• Published: Nature Publishing Group 2021-01-01
• Series: npj Breast Cancer
• Online Access: https://doi.org/10.1038/s41523-020-00207-3

Abstract Conventional CT scanners use energy-integrating detectors (EIDs). Photon-counting detector (PCD) computed tomography (CT) utilizes a CT detector technology based on smaller detector pixels capable of counting single photons and in addition discriminating their energy. Goal of this study was to explore the potential of higher spatial resolution for imaging of bone metastases. Four female patients with histologically confirmed breast cancer and bone metastases were included between July and October 2019. All patients underwent conventional EID CT scans followed by a high resolution non-contrast experimental PCD CT scan. Ultra-high resolution (UHR) reconstruction kernels were used to reconstruct axial slices with voxel sizes of 0.3 mm × 0.3 mm (inplane) × 1 mm (z-direction). Four radiologists blinded for patient identity assessed the images and compared the quality to conventional CT using a qualitative Likert scale. In this case series, we present images of bone metastases in breast cancer patients using an experimental PCD CT scanner and ultra-high-resolution kernels. A tendency to both a smaller inter-reader variability in the structural assessment of lesion sizes and in the readers’ opinion to an improved visualization of lesion margins and content was observed. In conclusion, while further studies are warranted, PCD CT has a high potential for therapy monitoring in breast cancer.