Hierarchical control of enzymatic actuators using DNA-based switchable memories

Hierarchical control of enzymatic actuators using DNA-based switchable memories

Naturally evolved regulatory circuits have hierarchical layers of signal generation and processing. Here, the authors emulate these networks using feedback-controlled DNA circuits that convert upstream signaling to downstream enzyme activity in a switchable memories circuit.

Bibliographic Details
Main Authors: Lenny H. H. Meijer, Alex Joesaar, Erik Steur, Wouter Engelen, Rutger A. van Santen, Maarten Merkx, Tom F. A. de Greef
Format: Article
Language:English
Published: Nature Publishing Group 2017-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01127-w
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spelling doaj-a0c209b4d05a45be9da69efaa3c736502021-05-11T07:27:49ZengNature Publishing GroupNature Communications2041-17232017-10-018111110.1038/s41467-017-01127-wHierarchical control of enzymatic actuators using DNA-based switchable memoriesLenny H. H. Meijer0Alex Joesaar1Erik Steur2Wouter Engelen3Rutger A. van Santen4Maarten Merkx5Tom F. A. de Greef6Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of TechnologyLaboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of TechnologyInstitute for Complex Molecular Systems, Eindhoven University of TechnologyLaboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of TechnologyInstitute for Complex Molecular Systems, Eindhoven University of TechnologyLaboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of TechnologyLaboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of TechnologyNaturally evolved regulatory circuits have hierarchical layers of signal generation and processing. Here, the authors emulate these networks using feedback-controlled DNA circuits that convert upstream signaling to downstream enzyme activity in a switchable memories circuit.https://doi.org/10.1038/s41467-017-01127-w
collection DOAJ
language English
format Article
sources DOAJ
author Lenny H. H. Meijer
Alex Joesaar
Erik Steur
Wouter Engelen
Rutger A. van Santen
Maarten Merkx
Tom F. A. de Greef
spellingShingle Lenny H. H. Meijer
Alex Joesaar
Erik Steur
Wouter Engelen
Rutger A. van Santen
Maarten Merkx
Tom F. A. de Greef
Hierarchical control of enzymatic actuators using DNA-based switchable memories
Nature Communications
author_facet Lenny H. H. Meijer
Alex Joesaar
Erik Steur
Wouter Engelen
Rutger A. van Santen
Maarten Merkx
Tom F. A. de Greef
author_sort Lenny H. H. Meijer
title Hierarchical control of enzymatic actuators using DNA-based switchable memories
title_short Hierarchical control of enzymatic actuators using DNA-based switchable memories
title_full Hierarchical control of enzymatic actuators using DNA-based switchable memories
title_fullStr Hierarchical control of enzymatic actuators using DNA-based switchable memories
title_full_unstemmed Hierarchical control of enzymatic actuators using DNA-based switchable memories
title_sort hierarchical control of enzymatic actuators using dna-based switchable memories
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-10-01
description Naturally evolved regulatory circuits have hierarchical layers of signal generation and processing. Here, the authors emulate these networks using feedback-controlled DNA circuits that convert upstream signaling to downstream enzyme activity in a switchable memories circuit.
url https://doi.org/10.1038/s41467-017-01127-w
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AT eriksteur hierarchicalcontrolofenzymaticactuatorsusingdnabasedswitchablememories
AT wouterengelen hierarchicalcontrolofenzymaticactuatorsusingdnabasedswitchablememories
AT rutgeravansanten hierarchicalcontrolofenzymaticactuatorsusingdnabasedswitchablememories
AT maartenmerkx hierarchicalcontrolofenzymaticactuatorsusingdnabasedswitchablememories
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