A comparison of Direct sequencing, Pyrosequencing, High resolution melting analysis, TheraScreen DxS, and the K-ras StripAssay for detecting <it>KRAS</it> mutations in non small cell lung carcinomas

A comparison of Direct sequencing, Pyrosequencing, High resolution melting analysis, TheraScreen DxS, and the K-ras StripAssay for detecting <it>KRAS</it> mutations in non small cell lung carcinomas

<p>Abstract</p> <p>Background</p> <p>It is mandatory to confirm the absence of mutations in the <it>KRAS</it> gene before treating metastatic colorectal cancers with epidermal growth factor receptor inhibitors, and similar regulations are being considered fo...

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Main Authors: Jancik Sylwia, Drabek Jiri, Berkovcova Jitka, Xu Yong, Stankova Marcela, Klein Jiri, Kolek Vitezslav, Skarda Josef, Tichy Tomas, Grygarkova Ivona, Radzioch Danuta, Hajduch Marian
Format: Article
Language:English
Published: BMC 2012-09-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
SNP - single nucleotide polymorphism
KRAS - Kiras2 kristen rat sarcoma viral oncogene homolog
NSCLC - Non-small cell lung cancer
Genotyping
Online Access:http://www.jeccr.com/content/31/1/79

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