Activation of PLCβ1 enhances endocannabinoid mobilization to restore hippocampal spike-timing-dependent potentiation and contextual fear memory impaired by Alzheimer’s amyloidosis

Activation of PLCβ1 enhances endocannabinoid mobilization to restore hippocampal spike-timing-dependent potentiation and contextual fear memory impaired by Alzheimer’s amyloidosis

Abstract Background Accumulation of amyloid beta oligomers (AβO) in Alzheimer’s disease (AD) impairs hippocampal long-term potentiation (LTP), leading to memory deficits. Thus, identifying the molecular targets of AβO involved in LTP inhibition is critical for developing therapeutics for AD. Endocan...

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Bibliographic Details
Main Authors: Jaedong Lee, Jeehyun Kwag
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Hippocampus
Endocannabinoid mobilization
PLCβ1
Long-term potentiation
Contextual fear memory
Online Access:https://doi.org/10.1186/s13195-021-00901-9

Internet

https://doi.org/10.1186/s13195-021-00901-9

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