Modulatory mechanisms underlying high-frequency transcranial random noise stimulation (hf-tRNS): A combined stochastic resonance and equivalent noise approach

• Main Authors: Andrea Pavan, Filippo Ghin, Adriano Contillo, Chiara Milesi, Gianluca Campana, George Mather
• Format: Article
• Language: English
• Published: Elsevier 2019-07-01
• Series: Brain Stimulation
• Subjects: Global motion; High-frequency transcranial random noise stimulation; Stochastic resonance; Internal noise; Global sampling
• Online Access: http://www.sciencedirect.com/science/article/pii/S1935861X19300713

Background: High-frequency transcranial random noise stimulation (hf-tRNS) is a neuromodulatory technique consisting of the application of alternating current at random intensities and frequencies. hf-tRNS induces random neural activity in the system that may boost the sensitivity of neurons to weak inputs. Stochastic resonance is a nonlinear phenomenon whereby the addition of an optimal amount of noise results in performance enhancement, whereas further noise increments impair signal detection or discrimination. Objective: The aim of the study was to assess whether modulatory effects of hf-tRNS rely on the stochastic resonance phenomenon, and what is the specific neural mechanism producing stochastic resonance. Method: Observers performed a two-interval forced choice motion direction discrimination task in which they had to report whether two moving patches presented in two temporal intervals had the same or different motion directions. hf-tRNS was administered at five intensity levels (0.5, 0.75, 1.0, 1.5, and 2.25 mA). Results: The results showed a significant improvement in performance when hf-tRNS was applied at 1.5 mA, representing the optimal level of external noise. However, stimulation intensity at 2.25 mA significantly impaired direction discrimination performance. An equivalent noise (EN) analysis, used to assess how hf-tRNS modulates the mechanisms underlying global motion processing, showed an increment in motion signal integration with the optimal current intensity, but reduced motion signal integration at 2.25 mA. Conclusion: These results indicate that hf-tRNS-induced noise modulates neural signal-to-noise ratio in a way that is compatible with the stochastic resonance phenomenon.