miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers

miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers

Cancer-associated fibroblasts (CAFs) are an important part of the tumor microenvironment. Here the authors characterize four subsets of CAFs across human samples of ovarian cancer subtypes and show in the mesenchymal subtype a specific CAF-S1 population that attracts immunosuppressive Tregs via CXCL...

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Main Authors: Anne-Marie Givel, Yann Kieffer, Alix Scholer-Dahirel, Philemon Sirven, Melissa Cardon, Floriane Pelon, Ilaria Magagna, Géraldine Gentric, Ana Costa, Claire Bonneau, Virginie Mieulet, Anne Vincent-Salomon, Fatima Mechta-Grigoriou
Format: Article
Language:English
Published: Nature Publishing Group 2018-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03348-z
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spelling doaj-a09f89d7e4cd4d8ebd1d78403faf2e102021-05-11T09:27:58ZengNature Publishing GroupNature Communications2041-17232018-03-019112010.1038/s41467-018-03348-zmiR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancersAnne-Marie Givel0Yann Kieffer1Alix Scholer-Dahirel2Philemon Sirven3Melissa Cardon4Floriane Pelon5Ilaria Magagna6Géraldine Gentric7Ana Costa8Claire Bonneau9Virginie Mieulet10Anne Vincent-Salomon11Fatima Mechta-Grigoriou12Institut Curie, Stress and Cancer Laboratory, Equipe labelisée Ligue Nationale Contre le Cancer, PSL Research UniversityInstitut Curie, Stress and Cancer Laboratory, Equipe labelisée Ligue Nationale Contre le Cancer, PSL Research UniversityInstitut Curie, Stress and Cancer Laboratory, Equipe labelisée Ligue Nationale Contre le Cancer, PSL Research UniversityInstitut Curie, Integrative Biology of Human Dendritic Cells and T Cells Laboratory, PSL Research University, U932, InsermInstitut Curie, Stress and Cancer Laboratory, Equipe labelisée Ligue Nationale Contre le Cancer, PSL Research UniversityInstitut Curie, Stress and Cancer Laboratory, Equipe labelisée Ligue Nationale Contre le Cancer, PSL Research UniversityInstitut Curie, Stress and Cancer Laboratory, Equipe labelisée Ligue Nationale Contre le Cancer, PSL Research UniversityInstitut Curie, Stress and Cancer Laboratory, Equipe labelisée Ligue Nationale Contre le Cancer, PSL Research UniversityInstitut Curie, Stress and Cancer Laboratory, Equipe labelisée Ligue Nationale Contre le Cancer, PSL Research UniversityInstitut Curie, Stress and Cancer Laboratory, Equipe labelisée Ligue Nationale Contre le Cancer, PSL Research UniversityInstitut Curie, Stress and Cancer Laboratory, Equipe labelisée Ligue Nationale Contre le Cancer, PSL Research UniversityDepartment of Pathology, Institut Curie Hospital GroupInstitut Curie, Stress and Cancer Laboratory, Equipe labelisée Ligue Nationale Contre le Cancer, PSL Research UniversityCancer-associated fibroblasts (CAFs) are an important part of the tumor microenvironment. Here the authors characterize four subsets of CAFs across human samples of ovarian cancer subtypes and show in the mesenchymal subtype a specific CAF-S1 population that attracts immunosuppressive Tregs via CXCL12β.https://doi.org/10.1038/s41467-018-03348-z
collection DOAJ
language English
format Article
sources DOAJ
author Anne-Marie Givel
Yann Kieffer
Alix Scholer-Dahirel
Philemon Sirven
Melissa Cardon
Floriane Pelon
Ilaria Magagna
Géraldine Gentric
Ana Costa
Claire Bonneau
Virginie Mieulet
Anne Vincent-Salomon
Fatima Mechta-Grigoriou
spellingShingle Anne-Marie Givel
Yann Kieffer
Alix Scholer-Dahirel
Philemon Sirven
Melissa Cardon
Floriane Pelon
Ilaria Magagna
Géraldine Gentric
Ana Costa
Claire Bonneau
Virginie Mieulet
Anne Vincent-Salomon
Fatima Mechta-Grigoriou
miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers
Nature Communications
author_facet Anne-Marie Givel
Yann Kieffer
Alix Scholer-Dahirel
Philemon Sirven
Melissa Cardon
Floriane Pelon
Ilaria Magagna
Géraldine Gentric
Ana Costa
Claire Bonneau
Virginie Mieulet
Anne Vincent-Salomon
Fatima Mechta-Grigoriou
author_sort Anne-Marie Givel
title miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers
title_short miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers
title_full miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers
title_fullStr miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers
title_full_unstemmed miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers
title_sort mir200-regulated cxcl12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-03-01
description Cancer-associated fibroblasts (CAFs) are an important part of the tumor microenvironment. Here the authors characterize four subsets of CAFs across human samples of ovarian cancer subtypes and show in the mesenchymal subtype a specific CAF-S1 population that attracts immunosuppressive Tregs via CXCL12β.
url https://doi.org/10.1038/s41467-018-03348-z
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