p38α MAPK Regulates Lineage Commitment and OPG Synthesis of Bone Marrow Stromal Cells to Prevent Bone Loss under Physiological and Pathological Conditions

p38α MAPK Regulates Lineage Commitment and OPG Synthesis of Bone Marrow Stromal Cells to Prevent Bone Loss under Physiological and Pathological Conditions

Bone marrow-derived mesenchymal stromal cells (BM-MSCs) are capable of differentiating into osteoblasts, chondrocytes, and adipocytes. Skewed differentiation of BM-MSCs contributes to the pathogenesis of osteoporosis. Yet how BM-MSC lineage commitment is regulated remains unclear. We show that ablat...

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Bibliographic Details
Main Authors: Qian Cong, Hao Jia, Soma Biswas, Ping Li, Shoutao Qiu, Qi Deng, Xizhi Guo, Gang Ma, Jenny Fang Ling Chau, Yibin Wang, Zhen-Lin Zhang, Xinquan Jiang, Huijuan Liu, Baojie Li
Format: Article
Language:English
Published: Elsevier 2016-04-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671116000345

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