Enhancing the Activation and Releasing the Brakes: A Double Hit Strategy to Improve NK Cell Cytotoxicity Against Multiple Myeloma

Enhancing the Activation and Releasing the Brakes: A Double Hit Strategy to Improve NK Cell Cytotoxicity Against Multiple Myeloma

Natural killer (NK) cells are innate lymphocytes with a strong antitumor ability. In tumor patients, such as multiple myeloma (MM) patients, an elevated number of NK cells after stem cell transplantation (SCT) has been reported to be correlated with a higher overall survival rate. With the aim of im...

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Bibliographic Details
Main Authors: Sara Tognarelli, Sebastian Wirsching, Ivana von Metzler, Bushra Rais, Benedikt Jacobs, Hubert Serve, Peter Bader, Evelyn Ullrich
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
multiple myeloma
autologous stem cell transplantation
NK cells
adoptive cell therapy
NKG2A blocking
checkpoint inhibition
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02743/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02743/full

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