The Clinical Significance of Phosphorylated Heat Shock Protein 27 (HSPB1) in Pancreatic Cancer

Pancreatic cancer is one of most aggressive forms of cancer. After clinical detection it exhibits fast metastatic growth. Heat shock protein 27 (HSP27; HSPB1) has been characterized as a molecular chaperone which modifies the structures and functions of other proteins in cells when they are exposed...

Full description

Bibliographic Details
Main Authors:	Mitsuru Okuno, Seiji Adachi, Osamu Kozawa, Masahito Shimizu, Ichiro Yasuda
Format:	Article
Language:	English
Published:	MDPI AG 2016-01-01
Series:	International Journal of Molecular Sciences
Subjects:	HSP27 pancreatic cancer phosphorylated HSP27 chemosensitivity prognosis
Online Access:	http://www.mdpi.com/1422-0067/17/1/137

id	doaj-a08780ada86b4b039f2a46e863f0dc78
record_format	Article
spelling	doaj-a08780ada86b4b039f2a46e863f0dc782020-11-24T21:55:12ZengMDPI AGInternational Journal of Molecular Sciences1422-00672016-01-0117113710.3390/ijms17010137ijms17010137The Clinical Significance of Phosphorylated Heat Shock Protein 27 (HSPB1) in Pancreatic CancerMitsuru Okuno0Seiji Adachi1Osamu Kozawa2Masahito Shimizu3Ichiro Yasuda4Department of Gastroenterology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, JapanDepartment of Gastroenterology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, JapanDepartment of Pharmacology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, JapanDepartment of Gastroenterology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, JapanDepartment of Gastroenterology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, JapanPancreatic cancer is one of most aggressive forms of cancer. After clinical detection it exhibits fast metastatic growth. Heat shock protein 27 (HSP27; HSPB1) has been characterized as a molecular chaperone which modifies the structures and functions of other proteins in cells when they are exposed to various stresses, such as chemotherapy. While the administration of gemcitabine, an anti-tumor drug, has been the standard treatment for patients with advanced pancreatic cancer, accumulating evidence shows that HSP27 plays a key role in the chemosensitivity to gemcitabine. In addition, phosphorylated HSP27 induced by gemcitabine has been associated with the inhibition of pancreatic cancer cell growth. In this review, we summarize the role of phosphorylated HSP27, as well as HSP27, in the regulation of chemosensitivity in pancreatic cancer.http://www.mdpi.com/1422-0067/17/1/137HSP27pancreatic cancerphosphorylated HSP27chemosensitivityprognosis
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Mitsuru Okuno Seiji Adachi Osamu Kozawa Masahito Shimizu Ichiro Yasuda
spellingShingle	Mitsuru Okuno Seiji Adachi Osamu Kozawa Masahito Shimizu Ichiro Yasuda The Clinical Significance of Phosphorylated Heat Shock Protein 27 (HSPB1) in Pancreatic Cancer International Journal of Molecular Sciences HSP27 pancreatic cancer phosphorylated HSP27 chemosensitivity prognosis
author_facet	Mitsuru Okuno Seiji Adachi Osamu Kozawa Masahito Shimizu Ichiro Yasuda
author_sort	Mitsuru Okuno
title	The Clinical Significance of Phosphorylated Heat Shock Protein 27 (HSPB1) in Pancreatic Cancer
title_short	The Clinical Significance of Phosphorylated Heat Shock Protein 27 (HSPB1) in Pancreatic Cancer
title_full	The Clinical Significance of Phosphorylated Heat Shock Protein 27 (HSPB1) in Pancreatic Cancer
title_fullStr	The Clinical Significance of Phosphorylated Heat Shock Protein 27 (HSPB1) in Pancreatic Cancer
title_full_unstemmed	The Clinical Significance of Phosphorylated Heat Shock Protein 27 (HSPB1) in Pancreatic Cancer
title_sort	clinical significance of phosphorylated heat shock protein 27 (hspb1) in pancreatic cancer
publisher	MDPI AG
series	International Journal of Molecular Sciences
issn	1422-0067
publishDate	2016-01-01
description	Pancreatic cancer is one of most aggressive forms of cancer. After clinical detection it exhibits fast metastatic growth. Heat shock protein 27 (HSP27; HSPB1) has been characterized as a molecular chaperone which modifies the structures and functions of other proteins in cells when they are exposed to various stresses, such as chemotherapy. While the administration of gemcitabine, an anti-tumor drug, has been the standard treatment for patients with advanced pancreatic cancer, accumulating evidence shows that HSP27 plays a key role in the chemosensitivity to gemcitabine. In addition, phosphorylated HSP27 induced by gemcitabine has been associated with the inhibition of pancreatic cancer cell growth. In this review, we summarize the role of phosphorylated HSP27, as well as HSP27, in the regulation of chemosensitivity in pancreatic cancer.
topic	HSP27 pancreatic cancer phosphorylated HSP27 chemosensitivity prognosis
url	http://www.mdpi.com/1422-0067/17/1/137
work_keys_str_mv	AT mitsuruokuno theclinicalsignificanceofphosphorylatedheatshockprotein27hspb1inpancreaticcancer AT seijiadachi theclinicalsignificanceofphosphorylatedheatshockprotein27hspb1inpancreaticcancer AT osamukozawa theclinicalsignificanceofphosphorylatedheatshockprotein27hspb1inpancreaticcancer AT masahitoshimizu theclinicalsignificanceofphosphorylatedheatshockprotein27hspb1inpancreaticcancer AT ichiroyasuda theclinicalsignificanceofphosphorylatedheatshockprotein27hspb1inpancreaticcancer AT mitsuruokuno clinicalsignificanceofphosphorylatedheatshockprotein27hspb1inpancreaticcancer AT seijiadachi clinicalsignificanceofphosphorylatedheatshockprotein27hspb1inpancreaticcancer AT osamukozawa clinicalsignificanceofphosphorylatedheatshockprotein27hspb1inpancreaticcancer AT masahitoshimizu clinicalsignificanceofphosphorylatedheatshockprotein27hspb1inpancreaticcancer AT ichiroyasuda clinicalsignificanceofphosphorylatedheatshockprotein27hspb1inpancreaticcancer
_version_	1725864125414768640

The Clinical Significance of Phosphorylated Heat Shock Protein 27 (HSPB1) in Pancreatic Cancer

Similar Items