Apolipoprotein E: isoform specific differences in tertiary structure and interaction with amyloid-β in human Alzheimer brain.

Apolipoprotein E: isoform specific differences in tertiary structure and interaction with amyloid-β in human Alzheimer brain.

We applied a novel application of FLIM-FRET to in situ measurement and quantification of protein interactions to explore isoform specific differences in Aβ-ApoE interaction and ApoE tertiary conformation in senile plaques in human Alzheimer brain. ApoE3 interacts more closely with Aβ than ApoE4, but...

Full description

Bibliographic Details
Main Authors: Phillip B Jones, Kenneth W Adams, Anete Rozkalne, Tara L Spires-Jones, Tammy T Hshieh, Tadafumi Hashimoto, Christine A F von Armin, Mathew Mielke, Brian J Bacskai, Bradley T Hyman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21297948/pdf/?tool=EBI

Similar Items

Similar Items