PREVALENCE OF ACINETOBACTER BAUMANNII ISOLATED FROM CLINICAL SPECIMENS IN ADAM MALIK HOSPITAL

• Main Authors: Evita Mayasari, Cherry Siregar
• Format: Article
• Language: English
• Published: Faculty of Medicine Andalas University 2014-05-01
• Series: Majalah Kedokteran Andalas
• Subjects: A. baumannii; spesimen klinis; pola kepekaan; carbapenem-resistent A.baumannii; A.baumannii; clinical specimens; susceptibility pattern
• Online Access: http://jurnalmka.fk.unand.ac.id/index.php/art/article/view/132
• ISSN: 0126-2092; 2442-5230

<p>Abstrak<br />Acinetobacter baumannii merupakan spesies Acinetobacter spp. tersering diisolasi dari<br />manusia, dan lebih sering dijumpai pada infeksi nosokomial dibandingkan dengan infeksi di<br />komunitas. Eksistensi bakteri ini di lingkungan terkait dengan keragaman reservoir, kemampuan<br />memperoleh gen pembawa sifat resisten antimikroba, dan sifat resisten terhadap pengeringan.<br />Infeksi disebabkan strain A.baumannii yang resisten terhadap banyak antibiotik tidak mudah<br />dikendalikan dan menjadi permasalahan di berbagai negara. Penelitian ini bertujuan untuk<br />mengetahui prevalensi A.baumannii dari spesimen klinis di instalasi mikrobiologi klinik RSUP<br />Haji Adam Malik serta pola kepekaannya terhadap berbagai antibiotik. Identifikasi dan uji<br />kepekaan menggunakan mesin otomatis Vitek 2 dengan Advanced Expert System (AES).<br />Penelitian ini menemukan 644/3693 (17,44%) isolat A.baumannii dari berbagai spesimen klinis.<br />A.baumannii paling banyak diisolasi dari spesimen dahak. Penelitian ini menemukan 147/644<br />(23%) bahwa isolat carbapenem-resistent A.baumannii (imipenem dan meropenem). Sebagian<br />besar isolat sensitif terhadap colistin, amikacin dan tigecycline. Prevalensi A.baumanni yang<br />ditemukan pada penelitian ini adalah rendah namun resistensinya tinggi terhadap antibiotik<br />terutama golongan penicillin, cephalosporin dan fluoroquinolon.<br /><br />Abstract<br />Acinetobacter baumannii is the most frequent species of Acinetobacter spp. isolated from<br />humans and more common in nosocomial infection than it is in community acquired infection.<br />A.baumannii existence in environment is associated with the diversity of its reservoirs, its<br />capacity to accumulate genes of antimicrobial resistence, and its resistence to desiccation.<br />Infection of Multidrug resistent (MDR) strain of A.baumannii is not easy to manage and it has<br />become a problem in many countries. The aim of this retrospective study was to investigate<br />the prevalence of A.baumannii from routine clinical specimens sent to clinical microbiology<br />laboratory RSUP HAM Medan and its susceptibility pattern to various antibiotics. Identification<br />and susceptibility testing of A. baumannii was performed by Vitek 2 with Advanced Expert<br />System (AES). A total of 644/3693 (17.44%) A.baumannii isolates were identified from various<br />clinical specimens. From those isolates, there were 147 (23%) isolates of carbapenemresistent<br />A.baumannii (imipenem and meropenem). A.baumannii mainly isolated from sputum<br />specimens, and most isolates were highly sensitive to colistin, amikacin and tigecycline.<br />Low prevalence of A.baumannii was found in this study. However, the isolates showed high<br />resistence level to antibiotics, particularly penicillin, cephalosporin and fluoroquinolones.<br /><br /></p>