Impact of Channel Geometry on the Discrimination of Mechanically Impaired Red Blood Cells in Passive Microfluidics

Impact of Channel Geometry on the Discrimination of Mechanically Impaired Red Blood Cells in Passive Microfluidics

In this work, we aimed at the discrimination of mechanically impaired red blood cells (RBCs) using passive microfluidic approaches. We investigated the impact of the channel geometry on the behavior of healthy RBCs (hRBCs) and thermally rigidified RBCs (T-rRBCs) flowing in (i) a Unique and Long Cons...

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Main Authors: Amin Amirouche, Rosaria Ferrigno, Magalie Faivre
Format: Article
Language:English
Published: MDPI AG 2017-08-01
Series:Proceedings
Subjects:
passive microfluidics
Red Blood Cells (RBC)
mechanical characterization
deformability
Online Access:https://www.mdpi.com/2504-3900/1/4/512
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spelling doaj-a069204d28d548c6ade4200d9a8411d72020-11-25T00:47:54ZengMDPI AGProceedings2504-39002017-08-011451210.3390/proceedings1040512proceedings1040512Impact of Channel Geometry on the Discrimination of Mechanically Impaired Red Blood Cells in Passive MicrofluidicsAmin Amirouche0Rosaria Ferrigno1Magalie Faivre2Institut des Nanotechnologies de Lyon INL-UMR5270 CNRS, Université Lyon 1, F-69622 Villeurbanne, FranceInstitut des Nanotechnologies de Lyon INL-UMR5270 CNRS, Université Lyon 1, F-69622 Villeurbanne, FranceInstitut des Nanotechnologies de Lyon INL-UMR5270 CNRS, Université Lyon 1, F-69622 Villeurbanne, FranceIn this work, we aimed at the discrimination of mechanically impaired red blood cells (RBCs) using passive microfluidic approaches. We investigated the impact of the channel geometry on the behavior of healthy RBCs (hRBCs) and thermally rigidified RBCs (T-rRBCs) flowing in (i) a Unique and Long Constriction (ULC) and (ii) a series of Oscillating Width Constrictions (OWC). To confront the two geometries, we evaluated potential biomarkers for cell discrimination such as their speed V, deformation index D and relaxation time τ.https://www.mdpi.com/2504-3900/1/4/512passive microfluidicsRed Blood Cells (RBC)mechanical characterizationdeformability
collection DOAJ
language English
format Article
sources DOAJ
author Amin Amirouche
Rosaria Ferrigno
Magalie Faivre
spellingShingle Amin Amirouche
Rosaria Ferrigno
Magalie Faivre
Impact of Channel Geometry on the Discrimination of Mechanically Impaired Red Blood Cells in Passive Microfluidics
Proceedings
passive microfluidics
Red Blood Cells (RBC)
mechanical characterization
deformability
author_facet Amin Amirouche
Rosaria Ferrigno
Magalie Faivre
author_sort Amin Amirouche
title Impact of Channel Geometry on the Discrimination of Mechanically Impaired Red Blood Cells in Passive Microfluidics
title_short Impact of Channel Geometry on the Discrimination of Mechanically Impaired Red Blood Cells in Passive Microfluidics
title_full Impact of Channel Geometry on the Discrimination of Mechanically Impaired Red Blood Cells in Passive Microfluidics
title_fullStr Impact of Channel Geometry on the Discrimination of Mechanically Impaired Red Blood Cells in Passive Microfluidics
title_full_unstemmed Impact of Channel Geometry on the Discrimination of Mechanically Impaired Red Blood Cells in Passive Microfluidics
title_sort impact of channel geometry on the discrimination of mechanically impaired red blood cells in passive microfluidics
publisher MDPI AG
series Proceedings
issn 2504-3900
publishDate 2017-08-01
description In this work, we aimed at the discrimination of mechanically impaired red blood cells (RBCs) using passive microfluidic approaches. We investigated the impact of the channel geometry on the behavior of healthy RBCs (hRBCs) and thermally rigidified RBCs (T-rRBCs) flowing in (i) a Unique and Long Constriction (ULC) and (ii) a series of Oscillating Width Constrictions (OWC). To confront the two geometries, we evaluated potential biomarkers for cell discrimination such as their speed V, deformation index D and relaxation time τ.
topic passive microfluidics
Red Blood Cells (RBC)
mechanical characterization
deformability
url https://www.mdpi.com/2504-3900/1/4/512
work_keys_str_mv AT aminamirouche impactofchannelgeometryonthediscriminationofmechanicallyimpairedredbloodcellsinpassivemicrofluidics
AT rosariaferrigno impactofchannelgeometryonthediscriminationofmechanicallyimpairedredbloodcellsinpassivemicrofluidics
AT magaliefaivre impactofchannelgeometryonthediscriminationofmechanicallyimpairedredbloodcellsinpassivemicrofluidics
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