Transcriptional dynamics of the embryonic stem cell switch.

Transcriptional dynamics of the embryonic stem cell switch.

Recent ChIP experiments of human and mouse embryonic stem cells have elucidated the architecture of the transcriptional regulatory circuitry responsible for cell determination, which involves the transcription factors OCT4, SOX2, and NANOG. In addition to regulating each other through feedback loops...

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Bibliographic Details
Main Authors: Vijay Chickarmane, Carl Troein, Ulrike A Nuber, Herbert M Sauro, Carsten Peterson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-09-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.0020123

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