Reduction in subventricular zone-derived olfactory bulb neurogenesis in a rat model of Huntington's disease is accompanied by striatal invasion of neuroblasts.

Reduction in subventricular zone-derived olfactory bulb neurogenesis in a rat model of Huntington's disease is accompanied by striatal invasion of neuroblasts.

Huntington's disease (HD) is an inherited progressive neurodegenerative disorder caused by an expanded CAG repeat in exon 1 of the huntingtin gene (HTT). The primary neuropathology of HD has been attributed to the preferential degeneration of medium spiny neurons (MSN) in the striatum. Reports...

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Main Authors: Mahesh Kandasamy, Michael Rosskopf, Katrin Wagner, Barbara Klein, Sebastien Couillard-Despres, Herbert A Reitsamer, Michael Stephan, Huu Phuc Nguyen, Olaf Riess, Ulrich Bogdahn, Jürgen Winkler, Stephan von Hörsten, Ludwig Aigner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0116069

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https://doi.org/10.1371/journal.pone.0116069

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