Consequences of Inhibiting Amyloid Precursor Protein Processing Enzymes on Synaptic Function and Plasticity

Consequences of Inhibiting Amyloid Precursor Protein Processing Enzymes on Synaptic Function and Plasticity

Alzheimer's disease (AD) is a neurodegenerative disease, one of whose major pathological hallmarks is the accumulation of amyloid plaques comprised of aggregated β-amyloid (Aβ) peptides. It is now recognized that soluble Aβ oligomers may lead to synaptic dysfunctions early in AD pathology prece...

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Bibliographic Details
Main Authors:	Hui Wang, Andrea Megill, Kaiwen He, Alfredo Kirkwood, Hey-Kyoung Lee
Format:	Article
Language:	English
Published:	Hindawi Limited 2012-01-01
Series:	Neural Plasticity
Online Access:	http://dx.doi.org/10.1155/2012/272374

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