Morphological aspects of efficiency of the combined treatment of distal gastric cancer with preoperative irradiation

• Main Authors: Dumanskiy Y.V., Balashova O.I., Vlasenko D.L., Teteryadchenko T.E., Velichko I.N.
• Format: Article
• Language: Russian
• Published: Ministry of Health of Ukraine. Dnipropetrovsk Medical Academy 2009-01-01
• Series: Морфологія
• Subjects: gastric cancer; remote gamma therapy; therapeutic pathomorphism; results of treatment
• Online Access: http://www.morphology.dp.ua/_pub/MORPHO-2009-03-02/09dyvplt.pdf

The cancer of stomach continues to occupy one of leading places in the structure of oncologic pathology in Ukraine and in the world. The general goal of our research was an estimation of efficiency and comparison of results of the combined and surgical treatment of distal gastric cancer, and also investigation of dependence of the got results from the morphological features of tumor. From January, 1995 for December, 2002 in the Dnepropetrovsk regional clinical oncologic dispensary got treatment 345 patients by the cancer of lower third of body and antral department of stomach. From them 91 patient was treated by the combined method with the use of the neoadjuvant remote gamma therapy. Therapeutic pathomorphism of degrees III to IV was observed in 47.7% patients after neoadjuvant remote gamma therapy and was mostly expressed in G2 and G3 tumors. For these patients the indexes of lethality to 1 year went down; the results of 3 and 5 - years survivability, indexes of median of survivability were improved. The got results showed that the preoperative irradiation of distal gastric cancer allowed to improve the results of treatment of this category of patients.