Protective Effect of Melatonin Against Polymicrobial Sepsis Is Mediated by the Anti-bacterial Effect of Neutrophils
Sepsis is an infection- or toxin-mediated systemic inflammatory syndrome. Previous studies have shown that melatonin, the primary hormone produced by the pineal gland, attenuates the effect of polymicrobial infection-mediated septic shock in animals. However, the mechanism of the anti-septic effect...
Main Authors: | Li Xu, Wei Zhang, Minseok Kwak, LiJun Zhang, Peter C. W. Lee, Jun-O Jin |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2019-06-01
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Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.01371/full |
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