HPTE-Induced Embryonic Thymocyte Death and Alteration of Differentiation Is Not Rescued by ERα or GPER Inhibition but Is Exacerbated by Concurrent TCR Signaling

HPTE-Induced Embryonic Thymocyte Death and Alteration of Differentiation Is Not Rescued by ERα or GPER Inhibition but Is Exacerbated by Concurrent TCR Signaling

Organochlorine pesticides, such as DDT, methoxychlor, and their metabolites, have been characterized as endocrine disrupting chemicals (EDCs); suggesting that their modes of action involve interaction with or abrogation of endogenous endocrine function. This study examined whether embryonic thymocyt...

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Bibliographic Details
Main Authors: Eddie Avellaneda, Atalie Lim, Sara Moeller, Jacqueline Marquez, Priscilla Escalante Cobb, Cristina Zambrano, Aaditya Patel, Victoria Sanchez, K. Godde, Christine Broussard
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
endocrine disrupting chemicals
estrogenic endocrine disruptors
HPTE
embryonic thymocytes
T cell development
cell death
Online Access:https://www.mdpi.com/1422-0067/22/18/10138

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