Key Matrix Remodeling Enzymes: Functions and Targeting in Cancer

Key Matrix Remodeling Enzymes: Functions and Targeting in Cancer

Tissue functionality and integrity demand continuous changes in distribution of major components in the extracellular matrices (ECMs) under normal conditions aiming tissue homeostasis. Major matrix degrading proteolytic enzymes are matrix metalloproteinases (MMPs), plasminogen activators, atypical p...

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Bibliographic Details
Main Authors:	Zoi Piperigkou, Konstantina Kyriakopoulou, Christos Koutsakis, Stylianos Mastronikolis, Nikos K. Karamanos
Format:	Article
Language:	English
Published:	MDPI AG 2021-03-01
Series:	Cancers
Subjects:	extracellular matrix cancer matrix metalloproteinases hyaluronidases heparanase plasminogen activators
Online Access:	https://www.mdpi.com/2072-6694/13/6/1441

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