Inhibition of Akt phosphorylation attenuates resistance to TNF-α cytotoxic effects in MCF-7 cells, but not in their doxorubicin resistant derivatives

Inhibition of Akt phosphorylation attenuates resistance to TNF-α cytotoxic effects in MCF-7 cells, but not in their doxorubicin resistant derivatives

Objective(s): Acquisition of TNF-α resistance plays role in the onset and growth of malignant tumors. Previous studies have demonstrated that MCF-7 cell line and its doxorubicin resistant variant MCF-7/Adr are resistant against the cytotoxic effects of TNF-α. In this study, we investigated the role...

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Bibliographic Details
Main Authors: Morteza Ghandadi, Atieh Mohammadi, Javad Behravan, Khalil Abnous, Negin Haj-Ali, Melika Ehtesham Gharaee, Fatemeh Mosaffa
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2016-12-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
Akt
Breast carcinoma
Multidrug resistance
Protein kinase B
Tumor necrosis factor-alpha
Online Access:http://ijbms.mums.ac.ir/article_7924_27366752e88cfa530bddf636eeaf709d.pdf

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