No Association between 2008–09 Influenza Vaccine and Influenza A(H1N1)pdm09 Virus Infection, Manitoba, Canada, 2009
We conducted a population-based study in Manitoba, Canada, to investigate whether use of inactivated trivalent influenza vaccine (TIV) during the 2008–09 influenza season was associated with subsequent infection with influenza A(H1N1)pdm09 virus during the first wave of the 2009 pandemic. Data were...
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doaj-a036e86c11bc41a9a58d42794f7d6a4b2020-11-25T02:11:10ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592012-05-0118580181010.3201/eid1805.111596No Association between 2008–09 Influenza Vaccine and Influenza A(H1N1)pdm09 Virus Infection, Manitoba, Canada, 2009Salaheddin M. MahmudPaul Van CaeseeleGregory HammondCarol KurbisTim HildermanLawrence ElliottWe conducted a population-based study in Manitoba, Canada, to investigate whether use of inactivated trivalent influenza vaccine (TIV) during the 2008–09 influenza season was associated with subsequent infection with influenza A(H1N1)pdm09 virus during the first wave of the 2009 pandemic. Data were obtained from a provincewide population-based immunization registry and laboratory-based influenza surveillance system. The test-negative case–control study included 831 case-patients with confirmed influenza A(H1N1)pdm09 virus infection and 2,479 controls, participants with test results negative for influenza A and B viruses. For the association of TIV receipt with influenza A(H1N1)pdm09 virus infection, the fully adjusted odds ratio was 1.0 (95% CI 0.7–1.4). Among case-patients, receipt of 2008–09 TIV was associated with a statistically nonsignificant 49% reduction in risk for hospitalization. In agreement with study findings outside Canada, our study in Manitoba indicates that the 2008–09 TIV neither increased nor decreased the risk for infection with influenza A(H1N1)pdm09 virus.https://wwwnc.cdc.gov/eid/article/18/5/11-1596_articleepidemiologypandemic influenza A (H1N1), trivalent influenza vaccines, case-control study, influenza, Canadapandemic (H1N1) 2009pandemic (H1N1) 2009 viruspandemic A(H1N1)2009 viruspandemic influenza A (H1N1) 2009 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Salaheddin M. Mahmud Paul Van Caeseele Gregory Hammond Carol Kurbis Tim Hilderman Lawrence Elliott |
spellingShingle |
Salaheddin M. Mahmud Paul Van Caeseele Gregory Hammond Carol Kurbis Tim Hilderman Lawrence Elliott No Association between 2008–09 Influenza Vaccine and Influenza A(H1N1)pdm09 Virus Infection, Manitoba, Canada, 2009 Emerging Infectious Diseases epidemiology pandemic influenza A (H1N1), trivalent influenza vaccines, case-control study, influenza, Canada pandemic (H1N1) 2009 pandemic (H1N1) 2009 virus pandemic A(H1N1)2009 virus pandemic influenza A (H1N1) 2009 |
author_facet |
Salaheddin M. Mahmud Paul Van Caeseele Gregory Hammond Carol Kurbis Tim Hilderman Lawrence Elliott |
author_sort |
Salaheddin M. Mahmud |
title |
No Association between 2008–09 Influenza Vaccine and Influenza A(H1N1)pdm09 Virus Infection, Manitoba, Canada, 2009 |
title_short |
No Association between 2008–09 Influenza Vaccine and Influenza A(H1N1)pdm09 Virus Infection, Manitoba, Canada, 2009 |
title_full |
No Association between 2008–09 Influenza Vaccine and Influenza A(H1N1)pdm09 Virus Infection, Manitoba, Canada, 2009 |
title_fullStr |
No Association between 2008–09 Influenza Vaccine and Influenza A(H1N1)pdm09 Virus Infection, Manitoba, Canada, 2009 |
title_full_unstemmed |
No Association between 2008–09 Influenza Vaccine and Influenza A(H1N1)pdm09 Virus Infection, Manitoba, Canada, 2009 |
title_sort |
no association between 2008–09 influenza vaccine and influenza a(h1n1)pdm09 virus infection, manitoba, canada, 2009 |
publisher |
Centers for Disease Control and Prevention |
series |
Emerging Infectious Diseases |
issn |
1080-6040 1080-6059 |
publishDate |
2012-05-01 |
description |
We conducted a population-based study in Manitoba, Canada, to investigate whether use of inactivated trivalent influenza vaccine (TIV) during the 2008–09 influenza season was associated with subsequent infection with influenza A(H1N1)pdm09 virus during the first wave of the 2009 pandemic. Data were obtained from a provincewide population-based immunization registry and laboratory-based influenza surveillance system. The test-negative case–control study included 831 case-patients with confirmed influenza A(H1N1)pdm09 virus infection and 2,479 controls, participants with test results negative for influenza A and B viruses. For the association of TIV receipt with influenza A(H1N1)pdm09 virus infection, the fully adjusted odds ratio was 1.0 (95% CI 0.7–1.4). Among case-patients, receipt of 2008–09 TIV was associated with a statistically nonsignificant 49% reduction in risk for hospitalization. In agreement with study findings outside Canada, our study in Manitoba indicates that the 2008–09 TIV neither increased nor decreased the risk for infection with influenza A(H1N1)pdm09 virus. |
topic |
epidemiology pandemic influenza A (H1N1), trivalent influenza vaccines, case-control study, influenza, Canada pandemic (H1N1) 2009 pandemic (H1N1) 2009 virus pandemic A(H1N1)2009 virus pandemic influenza A (H1N1) 2009 |
url |
https://wwwnc.cdc.gov/eid/article/18/5/11-1596_article |
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