No Association between 2008–09 Influenza Vaccine and Influenza A(H1N1)pdm09 Virus Infection, Manitoba, Canada, 2009

We conducted a population-based study in Manitoba, Canada, to investigate whether use of inactivated trivalent influenza vaccine (TIV) during the 2008–09 influenza season was associated with subsequent infection with influenza A(H1N1)pdm09 virus during the first wave of the 2009 pandemic. Data were...

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Main Authors: Salaheddin M. Mahmud, Paul Van Caeseele, Gregory Hammond, Carol Kurbis, Tim Hilderman, Lawrence Elliott
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2012-05-01
Series:Emerging Infectious Diseases
Subjects:
Online Access:https://wwwnc.cdc.gov/eid/article/18/5/11-1596_article
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spelling doaj-a036e86c11bc41a9a58d42794f7d6a4b2020-11-25T02:11:10ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592012-05-0118580181010.3201/eid1805.111596No Association between 2008–09 Influenza Vaccine and Influenza A(H1N1)pdm09 Virus Infection, Manitoba, Canada, 2009Salaheddin M. MahmudPaul Van CaeseeleGregory HammondCarol KurbisTim HildermanLawrence ElliottWe conducted a population-based study in Manitoba, Canada, to investigate whether use of inactivated trivalent influenza vaccine (TIV) during the 2008–09 influenza season was associated with subsequent infection with influenza A(H1N1)pdm09 virus during the first wave of the 2009 pandemic. Data were obtained from a provincewide population-based immunization registry and laboratory-based influenza surveillance system. The test-negative case–control study included 831 case-patients with confirmed influenza A(H1N1)pdm09 virus infection and 2,479 controls, participants with test results negative for influenza A and B viruses. For the association of TIV receipt with influenza A(H1N1)pdm09 virus infection, the fully adjusted odds ratio was 1.0 (95% CI 0.7–1.4). Among case-patients, receipt of 2008–09 TIV was associated with a statistically nonsignificant 49% reduction in risk for hospitalization. In agreement with study findings outside Canada, our study in Manitoba indicates that the 2008–09 TIV neither increased nor decreased the risk for infection with influenza A(H1N1)pdm09 virus.https://wwwnc.cdc.gov/eid/article/18/5/11-1596_articleepidemiologypandemic influenza A (H1N1), trivalent influenza vaccines, case-control study, influenza, Canadapandemic (H1N1) 2009pandemic (H1N1) 2009 viruspandemic A(H1N1)2009 viruspandemic influenza A (H1N1) 2009
collection DOAJ
language English
format Article
sources DOAJ
author Salaheddin M. Mahmud
Paul Van Caeseele
Gregory Hammond
Carol Kurbis
Tim Hilderman
Lawrence Elliott
spellingShingle Salaheddin M. Mahmud
Paul Van Caeseele
Gregory Hammond
Carol Kurbis
Tim Hilderman
Lawrence Elliott
No Association between 2008–09 Influenza Vaccine and Influenza A(H1N1)pdm09 Virus Infection, Manitoba, Canada, 2009
Emerging Infectious Diseases
epidemiology
pandemic influenza A (H1N1), trivalent influenza vaccines, case-control study, influenza, Canada
pandemic (H1N1) 2009
pandemic (H1N1) 2009 virus
pandemic A(H1N1)2009 virus
pandemic influenza A (H1N1) 2009
author_facet Salaheddin M. Mahmud
Paul Van Caeseele
Gregory Hammond
Carol Kurbis
Tim Hilderman
Lawrence Elliott
author_sort Salaheddin M. Mahmud
title No Association between 2008–09 Influenza Vaccine and Influenza A(H1N1)pdm09 Virus Infection, Manitoba, Canada, 2009
title_short No Association between 2008–09 Influenza Vaccine and Influenza A(H1N1)pdm09 Virus Infection, Manitoba, Canada, 2009
title_full No Association between 2008–09 Influenza Vaccine and Influenza A(H1N1)pdm09 Virus Infection, Manitoba, Canada, 2009
title_fullStr No Association between 2008–09 Influenza Vaccine and Influenza A(H1N1)pdm09 Virus Infection, Manitoba, Canada, 2009
title_full_unstemmed No Association between 2008–09 Influenza Vaccine and Influenza A(H1N1)pdm09 Virus Infection, Manitoba, Canada, 2009
title_sort no association between 2008–09 influenza vaccine and influenza a(h1n1)pdm09 virus infection, manitoba, canada, 2009
publisher Centers for Disease Control and Prevention
series Emerging Infectious Diseases
issn 1080-6040
1080-6059
publishDate 2012-05-01
description We conducted a population-based study in Manitoba, Canada, to investigate whether use of inactivated trivalent influenza vaccine (TIV) during the 2008–09 influenza season was associated with subsequent infection with influenza A(H1N1)pdm09 virus during the first wave of the 2009 pandemic. Data were obtained from a provincewide population-based immunization registry and laboratory-based influenza surveillance system. The test-negative case–control study included 831 case-patients with confirmed influenza A(H1N1)pdm09 virus infection and 2,479 controls, participants with test results negative for influenza A and B viruses. For the association of TIV receipt with influenza A(H1N1)pdm09 virus infection, the fully adjusted odds ratio was 1.0 (95% CI 0.7–1.4). Among case-patients, receipt of 2008–09 TIV was associated with a statistically nonsignificant 49% reduction in risk for hospitalization. In agreement with study findings outside Canada, our study in Manitoba indicates that the 2008–09 TIV neither increased nor decreased the risk for infection with influenza A(H1N1)pdm09 virus.
topic epidemiology
pandemic influenza A (H1N1), trivalent influenza vaccines, case-control study, influenza, Canada
pandemic (H1N1) 2009
pandemic (H1N1) 2009 virus
pandemic A(H1N1)2009 virus
pandemic influenza A (H1N1) 2009
url https://wwwnc.cdc.gov/eid/article/18/5/11-1596_article
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