Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo

Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo

Differentiation-inducing factor-1 (DIF-1) produced by Dictyostelium discoideum strongly inhibits the proliferation of various types of cancer cells by suppression of the Wnt/β-catenin signal transduction pathway. In the present study, we examined the effect of differentiation-inducing factor-3 (DIF-...

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Bibliographic Details
Main Authors: Naoya Kubokura, Fumi Takahashi-Yanaga, Masaki Arioka, Tatsuya Yoshihara, Kazunobu Igawa, Katsuhiko Tomooka, Sachio Morimoto, Yoshimichi Nakatsu, Teruhisa Tsuzuki, Yusaku Nakabeppu, Takayuki Matsumoto, Takanari Kitazono, Toshiyuki Sasaguri
Format: Article
Language:English
Published: Elsevier 2015-04-01
Series:Journal of Pharmacological Sciences
Subjects:
c-Myc
cyclin D1
DIF-3
TCF7L2
Wnt/β-catenin signaling pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861315000614

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