Adult-Onset Still’s Disease: From Pathophysiology to Targeted Therapies

Adult-Onset Still’s Disease: From Pathophysiology to Targeted Therapies

Adult-onset Still’s disease (AOSD) is a systemic inflammatory disorder affecting primarily young individuals. The diagnosis is primarily clinical and necessitates the exclusion of a wide range of mimicking disorders. Given the lack of solid data in regard to the underlying pathogenetic mechanisms, t...

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Main Authors: Clio P. Mavragani, Evangelos G. Spyridakis, Michael Koutsilieris
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:International Journal of Inflammation
Online Access:http://dx.doi.org/10.1155/2012/879020
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spelling doaj-a01689e2726844b2903b2595cb8982ae2020-11-24T22:37:58ZengHindawi LimitedInternational Journal of Inflammation2090-80402042-00992012-01-01201210.1155/2012/879020879020Adult-Onset Still’s Disease: From Pathophysiology to Targeted TherapiesClio P. Mavragani0Evangelos G. Spyridakis1Michael Koutsilieris2Department of Experimental Physiology, School of Medicine, University of Athens, Athens 11527, GreeceDepartment of Experimental Physiology, School of Medicine, University of Athens, Athens 11527, GreeceDepartment of Experimental Physiology, School of Medicine, University of Athens, Athens 11527, GreeceAdult-onset Still’s disease (AOSD) is a systemic inflammatory disorder affecting primarily young individuals. The diagnosis is primarily clinical and necessitates the exclusion of a wide range of mimicking disorders. Given the lack of solid data in regard to the underlying pathogenetic mechanisms, treatment of AOSD has been for years largely empirical. Recent advances have revealed a pivotal role of several proinflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-18 (IL-18) in disease pathogenesis, giving rise to the development of new targeted therapies aiming at optimal disease control.http://dx.doi.org/10.1155/2012/879020
collection DOAJ
language English
format Article
sources DOAJ
author Clio P. Mavragani
Evangelos G. Spyridakis
Michael Koutsilieris
spellingShingle Clio P. Mavragani
Evangelos G. Spyridakis
Michael Koutsilieris
Adult-Onset Still’s Disease: From Pathophysiology to Targeted Therapies
International Journal of Inflammation
author_facet Clio P. Mavragani
Evangelos G. Spyridakis
Michael Koutsilieris
author_sort Clio P. Mavragani
title Adult-Onset Still’s Disease: From Pathophysiology to Targeted Therapies
title_short Adult-Onset Still’s Disease: From Pathophysiology to Targeted Therapies
title_full Adult-Onset Still’s Disease: From Pathophysiology to Targeted Therapies
title_fullStr Adult-Onset Still’s Disease: From Pathophysiology to Targeted Therapies
title_full_unstemmed Adult-Onset Still’s Disease: From Pathophysiology to Targeted Therapies
title_sort adult-onset still’s disease: from pathophysiology to targeted therapies
publisher Hindawi Limited
series International Journal of Inflammation
issn 2090-8040
2042-0099
publishDate 2012-01-01
description Adult-onset Still’s disease (AOSD) is a systemic inflammatory disorder affecting primarily young individuals. The diagnosis is primarily clinical and necessitates the exclusion of a wide range of mimicking disorders. Given the lack of solid data in regard to the underlying pathogenetic mechanisms, treatment of AOSD has been for years largely empirical. Recent advances have revealed a pivotal role of several proinflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-18 (IL-18) in disease pathogenesis, giving rise to the development of new targeted therapies aiming at optimal disease control.
url http://dx.doi.org/10.1155/2012/879020
work_keys_str_mv AT cliopmavragani adultonsetstillsdiseasefrompathophysiologytotargetedtherapies
AT evangelosgspyridakis adultonsetstillsdiseasefrompathophysiologytotargetedtherapies
AT michaelkoutsilieris adultonsetstillsdiseasefrompathophysiologytotargetedtherapies
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