5' long terminal repeat (LTR)-selective methylation of latently infected HIV-1 provirus that is demethylated by reactivation signals

5' long terminal repeat (LTR)-selective methylation of latently infected HIV-1 provirus that is demethylated by reactivation signals

<p>Abstract</p> <p>We previously described selective hypermethylation of the 5'-long terminal repeat (LTR) of HTLV-1 provirus <it>in vivo </it>and <it>in vitro</it>. This prompted us to analyze CpG methylation of the two LTRs of the HIV provirus in chro...

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Main Authors: Watanabe Toshiki, Koiwa Tsukasa, Hamano Akiko, Ishida Takaomi
Format: Article
Language:English
Published: BMC 2006-10-01
Series:Retrovirology
Online Access:http://www.retrovirology.com/content/3/1/69
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spelling doaj-a00a29b1263a46269080c9dd764a35c22020-11-25T00:29:09ZengBMCRetrovirology1742-46902006-10-01316910.1186/1742-4690-3-695' long terminal repeat (LTR)-selective methylation of latently infected HIV-1 provirus that is demethylated by reactivation signalsWatanabe ToshikiKoiwa TsukasaHamano AkikoIshida Takaomi<p>Abstract</p> <p>We previously described selective hypermethylation of the 5'-long terminal repeat (LTR) of HTLV-1 provirus <it>in vivo </it>and <it>in vitro</it>. This prompted us to analyze CpG methylation of the two LTRs of the HIV provirus in chronically infected cell lines. The results demonstrate selective hypermethylation of the 5' LTR of the HIV provirus in ACH-2 cells. Moreover, induction of viral gene expression by TNF-α resulted in demethylation of the 5'-LTR. These results suggest that selective epigenetic modification of the 5'LTR of the HIV-1 provirus may be an important mechanism by which proviral activity is suppressed.</p> http://www.retrovirology.com/content/3/1/69
collection DOAJ
language English
format Article
sources DOAJ
author Watanabe Toshiki
Koiwa Tsukasa
Hamano Akiko
Ishida Takaomi
spellingShingle Watanabe Toshiki
Koiwa Tsukasa
Hamano Akiko
Ishida Takaomi
5' long terminal repeat (LTR)-selective methylation of latently infected HIV-1 provirus that is demethylated by reactivation signals
Retrovirology
author_facet Watanabe Toshiki
Koiwa Tsukasa
Hamano Akiko
Ishida Takaomi
author_sort Watanabe Toshiki
title 5' long terminal repeat (LTR)-selective methylation of latently infected HIV-1 provirus that is demethylated by reactivation signals
title_short 5' long terminal repeat (LTR)-selective methylation of latently infected HIV-1 provirus that is demethylated by reactivation signals
title_full 5' long terminal repeat (LTR)-selective methylation of latently infected HIV-1 provirus that is demethylated by reactivation signals
title_fullStr 5' long terminal repeat (LTR)-selective methylation of latently infected HIV-1 provirus that is demethylated by reactivation signals
title_full_unstemmed 5' long terminal repeat (LTR)-selective methylation of latently infected HIV-1 provirus that is demethylated by reactivation signals
title_sort 5' long terminal repeat (ltr)-selective methylation of latently infected hiv-1 provirus that is demethylated by reactivation signals
publisher BMC
series Retrovirology
issn 1742-4690
publishDate 2006-10-01
description <p>Abstract</p> <p>We previously described selective hypermethylation of the 5'-long terminal repeat (LTR) of HTLV-1 provirus <it>in vivo </it>and <it>in vitro</it>. This prompted us to analyze CpG methylation of the two LTRs of the HIV provirus in chronically infected cell lines. The results demonstrate selective hypermethylation of the 5' LTR of the HIV provirus in ACH-2 cells. Moreover, induction of viral gene expression by TNF-α resulted in demethylation of the 5'-LTR. These results suggest that selective epigenetic modification of the 5'LTR of the HIV-1 provirus may be an important mechanism by which proviral activity is suppressed.</p>
url http://www.retrovirology.com/content/3/1/69
work_keys_str_mv AT watanabetoshiki 5longterminalrepeatltrselectivemethylationoflatentlyinfectedhiv1provirusthatisdemethylatedbyreactivationsignals
AT koiwatsukasa 5longterminalrepeatltrselectivemethylationoflatentlyinfectedhiv1provirusthatisdemethylatedbyreactivationsignals
AT hamanoakiko 5longterminalrepeatltrselectivemethylationoflatentlyinfectedhiv1provirusthatisdemethylatedbyreactivationsignals
AT ishidatakaomi 5longterminalrepeatltrselectivemethylationoflatentlyinfectedhiv1provirusthatisdemethylatedbyreactivationsignals
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